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Table 1 Demographic characteristics and risk factors for patients with acquired drug resistant TB during SCC

From: Later emergence of acquired drug resistance and its effect on treatment outcome in patients treated with Standard Short-Course Chemotherapy for tuberculosis

Characteristics

Pan-susceptible TB throughouta n = 1609(%)

Any acquired drug resistant TBb

Acquired MDR-TB vs. Pan-susceptible TB throughout

Acquired Non- MDR-TB vs. Pan-susceptible TB throughout

 

MDR-TBc n = 17(%)

Non-MDR-TBd n = 45(%)

OR (95 % CI)e

P value

OR(95 % CI)

P value

Age(years)

       

 <40

756(47.0)

1(5.9)

19(42.2)

Reference

 

Reference

 

 40–59

560(34.8)

13(76.5)

20(44.5)

17.5(2.3–134.6)

<0.001

1.4(0.8–2.7)

0.278

 ≥60

293(18.2)

3(17.6)

6(13.3)

7.7(0.8–74.7)

0.07g

0.8(0.3–2.1)

0.665

Gender

       

 Male

1160(72.1)

14(82.4)

35(77.8)

Reference

 

Reference

 

 Female

449(27.9)

3(17.6)

10(22.2)

0.6(0.2–1.9)

0.427g

0.7 (0.4–1.5)

0.401

BMIf (Kg/m2)

       

 BMI < 18.5

620(38.5)

3(17.6)

18(40.0)

Reference

 

Reference

 

 BMI ≥ 18.5

989(61.5)

14(82.4)

27(60.0)

2.9(0.8–10.2)

0.078

0.9(0.5–1.7)

0.842

Treatment history

       

 New

1407(87.4)

11(64.7)

38(84.4)

Reference

 

Reference

 

 Previously treated

202(12.6)

6(35.3)

7(15.6)

3.8(1.4–10.4)

0.015g

1.3(0.6–2.9)

0.550

  1. aPan-susceptible TB throughout in our study was defined as cases with TB strains susceptible to all four first-line anti-TB drugs including soniazid(H), rifampicin(R), ethambutol(E), and streptomycin(S) both pretreatment and throughout therapy
  2. bAny acquired drug resistant TB in our study was defined as cases with TB strains that were susceptible to all four first-line anti-TB drugs pretreatment, but developed resistance to at least one of the four drugs during SCC
  3. c MDR-TB was defined as TB that was at least resistant to both isoniazid and rifampicin
  4. dNon-MDR-TB in our study was defined as TB cases with any drug resistance pattern except MDR-TB
  5. eOR, odds ratio. CI, confidence interval
  6. fBMI, body mass index, calculated as the weight in kilograms divided by the square of the height in meters
  7. g P value was determined by Fisher’s Exact Test. Not indicated was determined by Pearson’s Chi-Square Test