Table 3 Within medication group analysis: logistic regression models for the exacerbator phenotype
| Â | Odds ratio | Lower CI | Upper CI | p-value |
|---|---|---|---|---|
A. Tiotropium/Inhaled corticosteroid/Long acting beta-agonist | ||||
 Age, years | 0.98 | 0.95 | 1.00 | 0.1 |
 Female Gender | 1.53 | 1.05 | 2.21 | 0.03 |
 African-American Race | 0.69 | 0.44 | 1.09 | 0.1 |
 FEV1 Percent Predicted | 1.00 | 0.98 | 1.02 | 0.9 |
 TLC by CT percent predicted | 1.01 | 0.99 | 1.02 | 0.3 |
 SGRQ Total Score | 1.02 | 1.00 | 1.03 | 0.02 |
 MMRC Score | 0.85 | 0.60 | 1.21 | 0.4 |
 BODE Score | 1.08 | 0.80 | 1.47 | 0.6 |
 Frequent Cough Symptom | 1.11 | 0.75 | 1.64 | 0.6 |
 Doctor's Diagnosis of Asthma | 1.19 | 0.98 | 1.45 | 0.08 |
 Hay Fever | 1.01 | 0.81 | 1.27 | 0.9 |
 Prior Pneumonia | 1.36 | 1.03 | 1.80 | 0.03 |
 GERD | 1.62 | 1.11 | 2.38 | 0.01 |
B. Tiotropium | ||||
 Age, years | 0.93 | 0.87 | 1.00 | 0.04 |
 Female Gender | 2.64 | 0.95 | 7.33 | 0.06 |
 African-American Race | 0.15 | 0.02 | 1.28 | 0.08 |
 FEV1 percent predicted | 1.02 | 0.99 | 1.06 | 0.1 |
 FEV1 change with bronchodilator (L) | 2.99 | 0.10 | 87.43 | 0.5 |
 TLC by CT percent predicted | 1.00 | 0.97 | 1.04 | 0.9 |
 Percent Gas Trapping | 1.06 | 1.02 | 1.11 | 0.01 |
 SGRQ Total Score | 1.01 | 0.98 | 1.04 | 0.4 |
 Frequent Cough Symptom | 1.69 | 0.64 | 4.47 | 0.3 |
 Doctor's Diagnosis of Asthma | 1.57 | 1.06 | 2.32 | 0.03 |
 GERD | 2.75 | 1.10 | 6.88 | 0.03 |
C. Long acting beta-agonist/inhaled corticosteroid | ||||
 Age, years | 1.00 | 0.96 | 1.03 | 0.8 |
 Female Gender | 1.90 | 1.19 | 3.05 | 0.01 |
 African-American Race | 0.71 | 0.39 | 1.29 | 0.3 |
 FEV1 percent predicted | 0.98 | 0.96 | 1.01 | 0.1 |
 Resting Oxygen Saturation (%) | 0.97 | 0.90 | 1.04 | 0.4 |
 6MWT distance | 1.00 | 1.00 | 1.00 | 0.5 |
 FEV1 change with bronchodilator (L) | 1.65 | 0.42 | 6.39 | 0.5 |
 TLC by CT percent predicted | 1.01 | 0.99 | 1.02 | 0.3 |
 Percent Emphysema | 1.02 | 0.99 | 1.04 | 0.2 |
 MMRC Score | 1.04 | 0.71 | 1.54 | 0.8 |
 SGRQ Total Score | 1.03 | 1.01 | 1.04 | 0.01 |
 BODE Score | 0.96 | 0.68 | 1.35 | 0.8 |
 Frequent Cough Symptom | 1.50 | 0.91 | 2.45 | 0.1 |
 Doctor's Diagnosis of Asthma | 1.00 | 0.77 | 1.29 | 1.0 |
 Hay Fever | 1.27 | 0.98 | 1.66 | 0.07 |
 Prior pneumonia | 1.35 | 0.99 | 1.84 | 0.06 |
 GERD | 1.96 | 1.21 | 3.15 | 0.01 |
 Cardiovascular disease | 1.68 | 0.96 | 2.91 | 0.07 |
D. Short acting bronchodilators | ||||
 Age, years | 1.01 | 0.97 | 1.05 | 0.8 |
 Female Gender | 2.56 | 1.30 | 5.03 | 0.01 |
 African-American Race | 0.53 | 0.23 | 1.21 | 0.1 |
 FEV1 percent predicted | 0.98 | 0.96 | 1.01 | 0.1 |
 Oxygen Therapy | 2.47 | 1.11 | 5.51 | 0.03 |
 FEV1 change with bronchodilator (L) | 5.60 | 0.97 | 32.41 | 0.05 |
 TLC by CT percent predicted | 1.00 | 0.98 | 1.03 | 0.7 |
 Percent Emphysema | 1.03 | 0.99 | 1.08 | 0.2 |
 BODE Score | 1.00 | 0.78 | 1.28 | 1.0 |
 Frequent Cough Symptom | 2.14 | 1.13 | 4.06 | 0.02 |
 Hay Fever | 1.19 | 0.86 | 1.64 | 0.3 |
 Prior Pneumonia | 1.08 | 0.75 | 1.56 | 0.7 |