Table 5 Head-to-head analysis: logistic regression models for the effect of tiotropium vs. long-acting beta-agonist/inhaled corticosteroid on exacerbator status
| Â | Odds ratio | Lower CI | Upper CI | p-value |
|---|---|---|---|---|
A. All subjects using either TIO or ICS ± LABA (N = 602) | ||||
 Tiotropium Usage | 0.69 | 0.45 | 1.06 | 0.09 |
 Doctor's Diagnosis of Asthma | 1.22 | 1.01 | 1.47 | 0.04 |
 Age (years) | 1.00 | 0.98 | 1.02 | 1.0 |
 MMRC Score | 0.97 | 0.75 | 1.25 | 0.8 |
 SGRQ Total Score | 1.03 | 1.01 | 1.04 | <0.001 |
 BODE Score | 1.08 | 0.92 | 1.26 | 0.4 |
 TLC by CT percent predicted | 1.02 | 1.00 | 1.03 | 0.01 |
B. Excluding subjects with doctor diagnosed asthma (N = 341) | ||||
 Tiotropium Usage | 0.56 | 0.31 | 1.00 | 0.05 |
 Age (years) | 1.00 | 0.96 | 1.03 | 0.9 |
 MMRC Score | 1.03 | 0.70 | 1.50 | 0.9 |
 SGRQ Total Score | 1.04 | 1.01 | 1.06 | <0.001 |
 BODE Score | 0.96 | 0.77 | 1.21 | 0.8 |
 TLC by CT percent predicted | 1.02 | 1.00 | 1.04 | 0.02 |
C. Only subjects with doctor diagnosed asthma (N = 198) | ||||
 Tiotropium Usage | 1.03 | 0.39 | 2.70 | 1.0 |
 Age (years) | 1.01 | 0.97 | 1.05 | 0.6 |
 MMRC Score | 0.89 | 0.59 | 1.35 | 0.6 |
 SGRQ Total Score | 1.02 | 1.00 | 1.04 | 0.06 |
 BODE Score | 1.21 | 0.94 | 1.57 | 0.1 |
 TLC by CT percent predicted | 1.01 | 0.99 | 1.03 | 0.2 |