Mean pulmonary arterial pressure as a prognostic indicator in connective tissue disease associated with interstitial lung disease: a retrospective cohort study

Table 1 Baseline characteristics of all patients with CTD-ILD

Variable		Range
Sex, M/F	33/41
Age, years	63.5 ± 1.1	38–78
BMI, kg/m²	23.0 ± 4.0	13.7–35.3
Smoking status, ever/never	31/43
CTD
RA/SSc/PMDM/SjS/MCTD/	24/14/14/11/5
SLE/overlap syndrome	1/5
Surgical lung biopsy, yes/no	33/41
Corticosteroids/immunosuppressant	23/10
FVC, % predicted	81.0 ± 19.1	38.3–127.0
DLco, % predicted	57.1 ± 19.2	22.6–113.6
RV, % predicted	81.2 ± 31.5	17.9–181.9
TLC, % predicted	80.3 ± 18.3	47.9–138.6
PaO_2, mmHg	80.8 ± 9.9	60.2–103.2
A-a gradient, mmHg	20.2 ± 11.5	−3.8–38.1
MPAP, mmHg	17.2 ± 5.5	8–36
CI, l/min/m²	3.59 ± 0.77	1.89–5.18
PVR, Wood units	127.3 ± 59.9	34.0–406.0
PVRI, Wood units/m²	223.5 ± 102.1	52.0–606.0

Age is presented as median ± SE. Data are presented as mean ± SD unless otherwise noted. BMI: body mass index; RA: rheumatoid arthritis; SSc: systemic sclerosis; PM/DM: polymyositis/dermatomyositis; SjS: Sjögren’s syndrome; MCTD: mixed connective tissue disease; SLE: systemic lupus erythematosus; FVC: forced vital capacity; DLco: diffusing capacity of the lung for carbon monoxide; RV: residual volume, TLC: total lung capacity, PaO₂: arterial oxygen tension; A-a gradient: alveolar-arterial O₂ tension gradient, MPAP: mean pulmonary arterial pressure; CI: cardiac index; PVR: pulmonary vascular resistance; PVRI: pulmonary vascular resistance index. N = 74 except for DLco (n = 72)

ISSN: 1471-2466