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Table 1 Demographic, functional and treatment characteristics of asthmatics classified by phenotypes and healthy subjects

From: Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory?

Ā 

Eosinophilic asthma

Neutrophilic asthma

Mixed granulocytic asthma

Paucigranulocytic asthma

Healthy subjects

p value

N (% of asthmatics)

350 (42)

134 (16)

31 (4)

318 (38)

194

-

Women, N (%)

184 (53)

95 (71)ā€”ā€ 

19 (61)

197 (62)

105 (54)

0.002

Age, years

49 (34ā€“60)*

52 (41ā€“61)ā€”*

61 (43ā€“71)ā€”*

43 (30ā€“54)

45 (27ā€“56)

0.0001

BMI

25.9ā€‰Ā±ā€‰4.9ā€”

25.3ā€‰Ā±ā€‰5.4

25.5ā€‰Ā±ā€‰4.6

26.1ā€‰Ā±ā€‰4.8ā€”

24.3ā€‰Ā±ā€‰4.1

0.0004

Atopy, N (%)

213 (63)ā€”

69 (52)ā€”

17 (57)ā€”

165 (53)ā€”

46 (28)

<0.001

Smoking status, N (%)

Ā Ā Ā Ā Ā Ā 

ā€ƒNon-smokers

190 (54)

73 (55)

19 (61)

162 (52)

109 (57)

>0.05

ā€ƒCurrent smokers

64 (18)

26 (20)

5 (16)

76 (24)

35 (18)

Ā 

ā€ƒEx-smokers

96 (27)

33 (25)

7 (23)

75 (24)

47 (25)

Ā 

FEV1, % predicted

81.2ā€‰Ā±ā€‰20.9ā€”*

81.6ā€‰Ā±ā€‰22.0ā€”*

81.6ā€‰Ā±ā€‰20.6ā€”

89.2ā€‰Ā±ā€‰18.2ā€”

108.0ā€‰Ā±ā€‰13.3

0.0001

FEV1/FVC, %

70.7ā€‰Ā±ā€‰11.1ā€”*

71.7ā€‰Ā±ā€‰11.5ā€”*

70.1ā€‰Ā±ā€‰10.5ā€”*

76.2ā€‰Ā±ā€‰9.0ā€”

82.1ā€‰Ā±ā€‰6.5

0.0001

FENO, ppb

43 (23ā€“82)*

20 (13ā€“33)ā€ Ā§

36 (21ā€“75)*

16 (12ā€“29)

/

0.0001

ICS therapy, N (%)

227 (65)

87 (65)

18 (58)

195 (61)

/

>0.05

ICS dosea

500 (0ā€“1000)

800 (0ā€“2000)

800 (0ā€“1600)

400 (0ā€“1000)

/

>0.05

OCS therapy, N (%)

21 (6)

9 (7)

2 (6)

14 (4)

/

>0.05

LABA, N (%)

209 (60)

80 (60)

20 (65)

181 (57)

/

>0.05

LTRA, N (%)

75 (21)

37 (28)

9 (29)

73 (23)

/

>0.05

Theophylline, N (%)

11 (3)

7 (5)

0 (0)

11 (3)

/

>0.05

  1. ā€” pā€‰<ā€‰0.005, comparison with healthy subjects
  2. * pā€‰<ā€‰0.005, comparison with paucigranulocytic asthma
  3. ā€  pā€‰<ā€‰0.005, comparison with eosinophilic asthma
  4. Ā§ pā€‰<ā€‰0.005, comparison with mixed granulocytic asthma
  5. aICS dose in beclomethasone dipropionate - chlorofluorocarbon equivalents
  6. Abbreviations: BMI body mass index; FENO fractional exhaled nitric oxide; FEV 1 forced expiratory volume in 1Ā s; FVC forced vital capacity; ICS inhaled corticosteroid; LABA long-acting Ī²2-agonist; LTRA leukotriene receptor antagonist; OCS oral corticosteroid