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Table 4 Sputum and blood cell counts of non-eosinophilic phenotypes classified by ICS treatment and healthy subjects

From: Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory?

Ā 

Paucigranulocytic asthma, not treated with ICS

Paucigranulocytic asthma, treated with ICS

ICS- vs ICS+

Neutrophilic asthma, not treated with ICS

Neutrophilic asthma, treated with ICS

ICS- vs ICS+

Healthy subjects

N

123

195

-

47

87

-

194

Sputum total non-squamous cell count (x 106/g)

0.93 (0.43ā€“2.12)

0.69 (0.36ā€“1.61)

NS

1.45 (0.82ā€“4.65)ā€”

2.10 (0.75ā€“8.02)ā€”

NS

0.64 (0.37ā€“1.30)

Sputum viability (%)

65 (48ā€“78)

64 (48ā€“75)

NS

78 (68ā€“87)ā€”

80 (68ā€“88)ā€”

NS

67 (53ā€“78)

Sputum squamous cells (%)

16 (7ā€“30)

19 (10ā€“37)

NS

18 (5ā€“30)

7 (2ā€“27)ā€”

NS

18 (10ā€“31)

Sputum eosinophils (x 103/g)

4 (0ā€“15)ā€”

2 (0ā€“10)ā€”

NS

2 (0ā€“28)ā€”

4 (0ā€“27)ā€”

NS

0 (0ā€“2)

Sputum neutrophils (x 103/g)

315 (97ā€“994)

245 (86ā€“710)

NS

1197 (707ā€“3776)ā€”

1879 (593ā€“7060)ā€”

NS

210 (63ā€“563)

Sputum macrophages (x 103/g)

451 (188ā€“864)ā€”

280 (154ā€“853)

NS

127 (33ā€“396)ā€”

182 (52ā€“436)

NS

285 (120ā€“568)

Sputum lymphocytes (x 103/g)

12 (3ā€“45)

10 (2ā€“24)

NS

15 (4ā€“41)

11 (1ā€“39)

NS

10 (4ā€“26)

Sputum epithelial cells (x 103/g)

48 (19ā€“113)

52 (25ā€“120)ā€”

NS

19 (4ā€“44)

18 (3ā€“73)

NS

35 (12ā€“86)

Blood leukocytes (x103/Ī¼L)a

6.87 (5.85ā€“8.51)ā€”

7.47 (6.32ā€“9.06)ā€”

NS

7.87 (6.41ā€“9.93)ā€”

7.71 (6.44ā€“10.06)ā€”

NS

6.12 (5.03ā€“7.37)

Blood eosinophils (/Ī¼L)a

145 (101ā€“217)ā€”

139 (74ā€“229)

NS

172 (63ā€“293)

123 (80ā€“215)

NS

106 (68ā€“172)

Blood neutrophils (/Ī¼L)a

3598 (2924ā€“5119)

4211 (3392ā€“5392)ā€”

NS

4804 (3158ā€“6021)ā€”

4885 (3403ā€“6969)ā€”

NS

3416 (2610ā€“4188)

Blood monocytes (/Ī¼L)a

461 (353ā€“592)

463 (370ā€“615)ā€”

NS

476 (387ā€“648)

519 (419ā€“669)ā€”

NS

399 (330ā€“550)

Blood lymphocytes (/Ī¼L)a

2352 (1891ā€“2967)ā€”

2321 (1900ā€“2855)ā€”

NS

2518 (1989ā€“3035)ā€”

2167 (1675ā€“2726)

NS

2009 (1611ā€“2386)

Blood basophils (/Ī¼L)a

35 (25ā€“52)

33 (24ā€“51)

NS

40 (29ā€“53)

33 (22ā€“50)

NS

34 (24ā€“46)

  1. a Data available for 96 healthy subjects
  2. ā€” pā€‰<ā€‰0.0042, comparison with healthy subjects
  3. Abbreviation: ICS inhaled corticosteroid