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Table 5 Eosinophilic inflammation of asthmatics classified by phenotypes (with a sputum eosinophil cutoff of 1.01Ā %) and healthy subjects

From: Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory?

Ā 

Eosinophilic asthma

Neutrophilic asthma

Mixed granulocytic asthma

Paucigranulocytic asthma

Healthy subjects

p value (Kruskal- Wallis test)

Sp. eosinophils ā‰„1.01Ā %

Sp. eosinophils <1.01Ā %

Sp. eosinophils ā‰„1.01Ā %

Sp. eosinophils <1.01Ā %

Sp. neutrophils <76Ā %

Sp. neutrophils ā‰„76Ā %

Sp. neutrophils ā‰„76Ā %

Sp. neutrophils <76Ā %

N (% of asthmatics)

429 (51)

106 (13)

59 (7)

239 (29)

194

-

Sputum eosinophils

Ā Ā Ā Ā Ā Ā 

ā€ƒx 103/g

127 (38ā€“471)ā€”*

0 (0ā€“9)ā€ Ā§

77 (31ā€“380)ā€”*

0 (0ā€“5)ā€”ā€”

0 (0ā€“2)

0.0001

ā€ƒ% of non-squamous cells

11.8 (4.0ā€“30.8)ā€”*

0.0 (0.0ā€“0.5)ā€ Ā§

3.0 (1.8ā€“6.0)ā€”*ā€ 

0.2 (0.0ā€“0.5)

0.0 (0.0ā€“0.4)

0.0001

Blood eosinophilsa

Ā Ā Ā Ā Ā Ā 

ā€ƒ/Ī¼L

289 (181ā€“444)ā€”*

123 (62ā€“220)ā€ Ā§

266 (126ā€“430)ā€”*

133 (78ā€“200)

106 (68ā€“172)

0.0001

ā€ƒ%

3.8 (2.4ā€“5.6)ā€”*

1.7 (0.9ā€“3.0)ā€ Ā§

2.9 (1.8ā€“5.6)ā€”*

1.9 (1.0ā€“2.7)

1.8 (1.0ā€“3.0)

0.0001

  1. aData available for 96 healthy subjects
  2. ā€” pā€‰<ā€‰0.005, comparison with healthy subjects
  3. ā€”ā€” pā€‰=ā€‰0.005, comparison with healthy subjects
  4. * pā€‰<ā€‰0.005, comparison with paucigranulocytic asthma
  5. ā€  pā€‰<ā€‰0.005, comparison with eosinophilic asthma
  6. Ā§ pā€‰<ā€‰0.005, comparison with mixed granulocytic asthma
  7. Abbreviation: Sp. sputum