Table 1 Patient characteristics

Demographics

Male

40 (59.7 %)

17 (47.2 %)

23 (74.2 %)

0.05

Age, years

64.9 (10.2)

62.0 (9.2)

68.2 (10.5)

0.01

Lung function

FEV₁, l

1.3 (0.6)

1.4 (0.8)

1.2 (0.4)

0.17

FEV₁, % pred

50.0 (20.3)

52.8 (23.3)

46.7 (16.0)

0.21

Tiffeneau index (%)

39.0 (13.2)

40.2 (13.7)

37.6 (12.7)

0.44

FRC^a, l

4.5 (1.1)

4.3 (0.9)

4.8 (1.3)

0.09

FRC^a, % pred

143.5 (35.0)

144.0 (35.8)

142.9 (34.5)

0.90

RV^b, l

3.5 (1.0)

3.4 (0.9)

3.6 (1.1)

0.26

RV^b, % pred

157.5 (50.4)

161.2 (51.2)

153.3 (50.1)

0.54

TLC^b, l

6.7 (1.3)

6.6 (1.1)

6.8 (1.5)

0.48

TLC^b, % pred

113.9 (17.9)

118.0 (16.6)

109.2 (18.3)

0.05

TLCO^b, mmol/min/kPa

4.5 (2.2)

4.9 (2.6)

4.0 (1.4)

0.23^e

TLCO^b, % pred

54.0 (21.4)

58.4 (24.7)

49.1 (16.0)

0.15^e

KCO^b

0.9 (0.3)

1.0 (0.3)

0.9 (0.3)

0.30

KCO^b, % pred

67.8 (23.1)

68.0 (24.8)

67.5 (21.5)

0.93

Clinical characteristics

BMI, kg/m²

27.1 (5.7)

27.9 (5.4)

26.1 (6.0)

0.19

Current Smokers

8 (11.9 %)

4 (11.1 %)

4 (12.9 %)

1.00

mMRC score, points^c

2.6 (0.9)

2.6 (0.9)

2.5 (1.0)

0.64

CAT score, points^d

23.3 (6.9)

25.4 (5.4)

21.0 (7.7)

0.01

HADS-A, points^d

7.8 (4.9)

8.8 (5.0)

6.6 (4.6)

0.08

HADS-D, points^d

8.0 (4.4)

9.1 (4.4)

6.8 (4.1)

0.03

6MWD, meters^a

411.5 (120.6)

404.5 (121.6)

419.7 (121.1)

0.62

6MWD, % pred^a

66.5 (19.5)

65.2 (20.1)

68.0 (19.1)

0.58

Comorbidities

Charlson comorbidity index score, points)

1.9 (1.3)

1.7 (1.1)

2.2 (1.6)

0.11^e

IHD

11 (16.4 %)

5 (13.9 %)

6 (19.4 %)

0.79

PAD

12 (17.9 %)

6 (16.7 %)

6 (19.4 %)

1.0

DM

10 (14.9 %)

4 (11.1 %)

6 (19.4 %)

0.55