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Table 1 Baseline characteristics of the subjects. Values presented are mean (SD) or number of subjects and proportion of subjects [n (%)]

From: Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters

Variable Severe Asthmatics (n = 77) Moderate Asthmatics (n = 48) p-value
Sputum Neutrophils (%) 49.0 (31.2) 43.1 (26.3) 0.32
Sputum Eosinophils (%) 11.8 (17.6) 4.6 (6.5) 0.01
Age 49.9 (12.6) 46.6 (11.2) 0.13
BMI 28.1 (5.8) 27.7 (6.9) 0.74
Age-of-Onset (AOO) 22.9 (18.0) 22.1 (14.7) 0.77
Beclamethasone or equivalent dose (mcg) 1340.7 (524.1) 677.2 (425.5) <0.01
FENO (ppb) 30.5 (28.6) 20.4 (18.2) 0.02
ACQ 2.0 (1.0) 1.0 (0.8) <0.01
FEV1(%) 63.4 (19.7) 87.2 (12.5) <0.01
FEV1/FVC 64.9 (12.2) 74.1 (8.5) <0.01
Prednisone user [n (%)] 41 (53 %) 2 (4 %) <0.01
Omalizumab user [n (%)] 8 (10 %) 0 (0 %) 0.02
Males [n (%)] 43 (56 %) 23 (48 %) 0.50
Non Smoker [n (%)] 52 (67.5 %) 25 (53 %) 0.16
Atopic [n (%)] 58 (81 %) 42 (87.5 %) 0.45
  1. Abbreviations: FEV 1 Forced Expiratory Volume at 1 s, ICS inhaled corticosteroid, AOO age of onset of asthma, ACQ Asthma Control Questionnaire score, BMI body mass index, F E NO fractional of exhaled nitric oxide in parts per billion (ppb)