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Table 1 Baseline characteristics of the subjects. Values presented are mean (SD) or number of subjects and proportion of subjects [n (%)]

From: Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters

Variable

Severe Asthmatics (n = 77)

Moderate Asthmatics (n = 48)

p-value

Sputum Neutrophils (%)

49.0 (31.2)

43.1 (26.3)

0.32

Sputum Eosinophils (%)

11.8 (17.6)

4.6 (6.5)

0.01

Age

49.9 (12.6)

46.6 (11.2)

0.13

BMI

28.1 (5.8)

27.7 (6.9)

0.74

Age-of-Onset (AOO)

22.9 (18.0)

22.1 (14.7)

0.77

Beclamethasone or equivalent dose (mcg)

1340.7 (524.1)

677.2 (425.5)

<0.01

FENO (ppb)

30.5 (28.6)

20.4 (18.2)

0.02

ACQ

2.0 (1.0)

1.0 (0.8)

<0.01

FEV1(%)

63.4 (19.7)

87.2 (12.5)

<0.01

FEV1/FVC

64.9 (12.2)

74.1 (8.5)

<0.01

Prednisone user [n (%)]

41 (53 %)

2 (4 %)

<0.01

Omalizumab user [n (%)]

8 (10 %)

0 (0 %)

0.02

Males [n (%)]

43 (56 %)

23 (48 %)

0.50

Non Smoker [n (%)]

52 (67.5 %)

25 (53 %)

0.16

Atopic [n (%)]

58 (81 %)

42 (87.5 %)

0.45

  1. Abbreviations: FEV 1 Forced Expiratory Volume at 1 s, ICS inhaled corticosteroid, AOO age of onset of asthma, ACQ Asthma Control Questionnaire score, BMI body mass index, F E NO fractional of exhaled nitric oxide in parts per billion (ppb)