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Table 2 Baseline Cluster Descriptive. Values shown are number of subjects, and percentage of total subjects [n (%)] unless stated

From: Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters

Variable Phenotype A (n = 15) Phenotype B (n = 17) Phenotype C (n = 39) Phenotype D (n = 54) p-value
FEV1 < 80 % 12 (80.0) 9 (52.9) 37 (94.9) 20 (37.0) <0.01
Beclamethasone or equivalent dose >1600mcg 7 (46.7) 2 (11.8) 6 (15.4) 4 (7.4) <0.01
AOO <20 year 3 (20.0) 7 (41.2) 31 (79.5) 17 (31.5) <0.01
ACQ ≤ 1 2 (13.3) 5 (29.4) 14 (35.9) 24 (44.4) 0.15
Female 6 (40.0) 10 (58.8) 12 (30.8) 31 (57.4) 0.05
Severe asthmatic 14 (93.3) 10 (58.8) 31 (79.5) 22 (40.7) <0.01
Atopic 11 (73.3) 13 (76.5) 34 (87.2) 42 (77.8) 0.58
Non-Smoker 9 (60.0) 13 (76.5) 28 (71.8) 27 (50.0) 0.09
Age [mean(SD)] 46.7 (13.4) 44.9 (8.8) 52.4 (12.6) 47.5 (11.9) 0.10
BMI [mean (SD)] 26.2 (3.8) 40.1 (4.4) 27.0 (3.9) 25.4 (3.7) <0.01
Sputum Neutrophils (%) [mean (SD)] 34.3 (27.4) 51.0 (24.8) 43.6 (29.2) 47.5 (29.3) 0.34
Sputum Eosinophils (%) [mean (SD)] 3.9 (5.3) 33.5 (16.7) 5.1 (6.5) 5.8 (6.0) <0.01
FENO ppb [mean (SD)] 28.7 (26.5) 25.5 (23.8) 29.7 (30.6) 24.0 (21.4) 0.74
  1. Abbreviations: FEV 1 Forced Expiratory Volume at 1 s, ICS inhaled corticosteroid, AOO age of onset of asthma, ACQ Asthma Control Questionnaire score, BMI body mass index, F E NO fractional of exhaled nitric oxide in parts per billion (ppb). Chi-square test was used for categorical variables, and one-way ANOVA was performed for continuous variables