Skip to main content

Table 2 Associations between cord blood YKL-40 levels and SNPs with asthma and atopy at school age

From: CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development

  Univariable association Multivariablea association
  OR 95 % CI P-value OR 95 % CI P-value
Exposure Outcome asthmab
SNP*  
 rs10920579 0.25 0.06–1.15 0.305 0.23 0.05–1.2 0.365
 rs880633 1.33 0.63–2.89 0.777 1.05 0.46–2.38 0.901
 rs10399931 0.21 0.05–0.95 0.212 0.21 0.04–0.98 0.287
 rs10399805 4.50 1.59–12.94 0.031 3.42 1.12–10.56 0.224
 rs1538372 0.74 0.31–1.72 0.777 0.68 0.28–1.63 0.901
 rs7542294 2.80 1.29–7.01 0.158 2.37 0.87–6.46 0.365
 rs2486064 0.89 0.42–1.91 0.777 0.94 0.42–2.19 0.901
YKL-40 (ng/ml)       
 YKL-40 non-detects 1 reference P trend 1 reference P trend
 YKL-40 (7–37.9) 0.86 0.13–5.54   0.82 0.12–5.67  
 YKL-40 (38–49.9) 1.21 0.22–6.43   1.45 0.24–8.61  
 YKL-40 (50–65.9) 1.72 0.35–8.38   2.27 0.41–12.2  
 YKL-40 (66–98) 2.24 0.49–10.24 0.218** 2.52 0.49–13.01 0.169**
Exposure Outcome atopyc
SNP*       
 rs10920579 0.56 0.26–1.14 0.691 0.50 0.24–1.05 0.714
 rs880633 0.92 0.55–1.51 0.96 0.94 0.57–1.56 0.913
 rs10399931 0.45 0.24–0.91 0.169 0.43 0.21–0.86 0.251
 rs10399805 1.43 0.64–3.19 0.96 1.63 0.71–3.75 0.913
 rs1538372 0.83 0.48–1.39 0.96 0.81 0.47–1.39 0.913
 rs7542294 1.25 0.62–2.55 0.96 1.37 0.66–2.81 0.913
 rs2486064 0.98 0.61–1.59 0.96 0.89 0.54–1.47 0.913
YKL-40 (ng/ml)       
 YKL-40 non-detects 1 reference P trend 1 reference P trend
 YKL-40 (7–37.9) 1.15 0.42–3.13   1.09 0.43–3.21  
 YKL-40 (38–49.9) 1 0.37–2.67   0.98 0.37–2.71  
 YKL-40 (50–65.9) 1.44 0.54–3.83   1.35 0.55–3.91  
 YKL-40 (66–98) 1.76 0.67–4.61 0.188** 1.69 0.66–4.58 0.232**
  1. CI Confidence interval, OR Odds ratio. SNP Single nucleotide polymorphism. Cord blood YKL-40 levels are compared with YKL-40 non-detects. aAdjusted for the following additional risk factors: sex, parental smoking during childhood, maternal atopy, parental education. bAsthma was diagnosed if one on the following was present in the previous year: (1) physician diagnosis of asthma or (2) episodic wheeze. Missing data on n = 7; data available for n = 135. cDefined if one of the following was present: asthma, allergic rhinitis, atopic eczema or positive prick test. Missing data on n = 4; data available for n = 138. * P-values for SNPs are shown after correction for multiple testing according to Benjamini-Hochberg. ** P trend-values were calculated with the Cochran-Armitage trend test