From: CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development
Univariable association | Multivariablea association | |||||
---|---|---|---|---|---|---|
OR | 95 % CI | P-value | OR | 95 % CI | P-value | |
Exposure | Outcome asthmab | |||||
SNP* | ||||||
rs10920579 | 0.25 | 0.06–1.15 | 0.305 | 0.23 | 0.05–1.2 | 0.365 |
rs880633 | 1.33 | 0.63–2.89 | 0.777 | 1.05 | 0.46–2.38 | 0.901 |
rs10399931 | 0.21 | 0.05–0.95 | 0.212 | 0.21 | 0.04–0.98 | 0.287 |
rs10399805 | 4.50 | 1.59–12.94 | 0.031 | 3.42 | 1.12–10.56 | 0.224 |
rs1538372 | 0.74 | 0.31–1.72 | 0.777 | 0.68 | 0.28–1.63 | 0.901 |
rs7542294 | 2.80 | 1.29–7.01 | 0.158 | 2.37 | 0.87–6.46 | 0.365 |
rs2486064 | 0.89 | 0.42–1.91 | 0.777 | 0.94 | 0.42–2.19 | 0.901 |
YKL-40 (ng/ml) | ||||||
YKL-40 non-detects | 1 | reference | P trend | 1 | reference | P trend |
YKL-40 (7–37.9) | 0.86 | 0.13–5.54 | 0.82 | 0.12–5.67 | ||
YKL-40 (38–49.9) | 1.21 | 0.22–6.43 | 1.45 | 0.24–8.61 | ||
YKL-40 (50–65.9) | 1.72 | 0.35–8.38 | 2.27 | 0.41–12.2 | ||
YKL-40 (66–98) | 2.24 | 0.49–10.24 | 0.218** | 2.52 | 0.49–13.01 | 0.169** |
Exposure | Outcome atopyc | |||||
SNP* | ||||||
rs10920579 | 0.56 | 0.26–1.14 | 0.691 | 0.50 | 0.24–1.05 | 0.714 |
rs880633 | 0.92 | 0.55–1.51 | 0.96 | 0.94 | 0.57–1.56 | 0.913 |
rs10399931 | 0.45 | 0.24–0.91 | 0.169 | 0.43 | 0.21–0.86 | 0.251 |
rs10399805 | 1.43 | 0.64–3.19 | 0.96 | 1.63 | 0.71–3.75 | 0.913 |
rs1538372 | 0.83 | 0.48–1.39 | 0.96 | 0.81 | 0.47–1.39 | 0.913 |
rs7542294 | 1.25 | 0.62–2.55 | 0.96 | 1.37 | 0.66–2.81 | 0.913 |
rs2486064 | 0.98 | 0.61–1.59 | 0.96 | 0.89 | 0.54–1.47 | 0.913 |
YKL-40 (ng/ml) | ||||||
YKL-40 non-detects | 1 | reference | P trend | 1 | reference | P trend |
YKL-40 (7–37.9) | 1.15 | 0.42–3.13 | 1.09 | 0.43–3.21 | ||
YKL-40 (38–49.9) | 1 | 0.37–2.67 | 0.98 | 0.37–2.71 | ||
YKL-40 (50–65.9) | 1.44 | 0.54–3.83 | 1.35 | 0.55–3.91 | ||
YKL-40 (66–98) | 1.76 | 0.67–4.61 | 0.188** | 1.69 | 0.66–4.58 | 0.232** |