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Table 2 Associations between cord blood YKL-40 levels and SNPs with asthma and atopy at school age

From: CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development

 

Univariable association

Multivariablea association

 

OR

95 % CI

P-value

OR

95 % CI

P-value

Exposure

Outcome asthmab

SNP*

 

 rs10920579

0.25

0.06–1.15

0.305

0.23

0.05–1.2

0.365

 rs880633

1.33

0.63–2.89

0.777

1.05

0.46–2.38

0.901

 rs10399931

0.21

0.05–0.95

0.212

0.21

0.04–0.98

0.287

 rs10399805

4.50

1.59–12.94

0.031

3.42

1.12–10.56

0.224

 rs1538372

0.74

0.31–1.72

0.777

0.68

0.28–1.63

0.901

 rs7542294

2.80

1.29–7.01

0.158

2.37

0.87–6.46

0.365

 rs2486064

0.89

0.42–1.91

0.777

0.94

0.42–2.19

0.901

YKL-40 (ng/ml)

      

 YKL-40 non-detects

1

reference

P trend

1

reference

P trend

 YKL-40 (7–37.9)

0.86

0.13–5.54

 

0.82

0.12–5.67

 

 YKL-40 (38–49.9)

1.21

0.22–6.43

 

1.45

0.24–8.61

 

 YKL-40 (50–65.9)

1.72

0.35–8.38

 

2.27

0.41–12.2

 

 YKL-40 (66–98)

2.24

0.49–10.24

0.218**

2.52

0.49–13.01

0.169**

Exposure

Outcome atopyc

SNP*

      

 rs10920579

0.56

0.26–1.14

0.691

0.50

0.24–1.05

0.714

 rs880633

0.92

0.55–1.51

0.96

0.94

0.57–1.56

0.913

 rs10399931

0.45

0.24–0.91

0.169

0.43

0.21–0.86

0.251

 rs10399805

1.43

0.64–3.19

0.96

1.63

0.71–3.75

0.913

 rs1538372

0.83

0.48–1.39

0.96

0.81

0.47–1.39

0.913

 rs7542294

1.25

0.62–2.55

0.96

1.37

0.66–2.81

0.913

 rs2486064

0.98

0.61–1.59

0.96

0.89

0.54–1.47

0.913

YKL-40 (ng/ml)

      

 YKL-40 non-detects

1

reference

P trend

1

reference

P trend

 YKL-40 (7–37.9)

1.15

0.42–3.13

 

1.09

0.43–3.21

 

 YKL-40 (38–49.9)

1

0.37–2.67

 

0.98

0.37–2.71

 

 YKL-40 (50–65.9)

1.44

0.54–3.83

 

1.35

0.55–3.91

 

 YKL-40 (66–98)

1.76

0.67–4.61

0.188**

1.69

0.66–4.58

0.232**

  1. CI Confidence interval, OR Odds ratio. SNP Single nucleotide polymorphism. Cord blood YKL-40 levels are compared with YKL-40 non-detects. aAdjusted for the following additional risk factors: sex, parental smoking during childhood, maternal atopy, parental education. bAsthma was diagnosed if one on the following was present in the previous year: (1) physician diagnosis of asthma or (2) episodic wheeze. Missing data on n = 7; data available for n = 135. cDefined if one of the following was present: asthma, allergic rhinitis, atopic eczema or positive prick test. Missing data on n = 4; data available for n = 138. * P-values for SNPs are shown after correction for multiple testing according to Benjamini-Hochberg. ** P trend-values were calculated with the Cochran-Armitage trend test