CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development

BMC Pulmonary Medicine

Table 3 Associations between SNPs and asthma at school age adjusted for cord blood YKL-40 levels

	Univariable association			Univariable association adjusted for YKL-40 levels
	OR	95 % CI	P-value	OR	95 % CI	P-value
Exposure	Outcome asthma^a
SNP^*
rs10920579	0.25	0.06–1.15	0.305	0.23	0.05–1.08	0.254
rs880633	1.33	0.63–2.89	0.777	1.27	0.59–2.75	0.654
rs10399931	0.21	0.05–0.95	0.212	0.2	0.04–0.89	0.189
rs10399805	4.50	1.59–12.94	0.031	4.76	1.66–13.62	0.026
rs1538372	0.74	0.31–1.72	0.777	0.71	0.31–1.68	0.654
rs7542294	2.80	1.29–7.01	0.158	2.66	1.06–6.72	0.189
rs2486064	0.89	0.42–1.91	0.777	0.84	0.39–1.81	0.654

CI Confidence interval, OR Odds ratio. SNP Single nucleotide polymorphism. ^aAsthma was diagnosed if one on the following was present in the previous year: (1) physician diagnosis of asthma or (2) episodic wheeze. Missing data on n = 7; data available for n = 135. ^* P-values for SNPs are shown after correction for multiple testing according to Benjamini-Hochberg

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