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Table 3 Association between vitamin D pathway genotype and susceptibility to active tuberculosis

From: Vitamin D deficiency associates with susceptibility to tuberculosis in Pakistan, but polymorphisms in VDR, DBP and CYP2R1 do not

SNP, gene Genotype TB cases, n/N (%) TB contacts, n/N (%) aOR (95 % CI)a P
rs7312236, VDR AA 84/230 (37 %) 42/100 (42 %) Ref -
AG/GG 146/230 (63 %) 58/100 (58 %) 1.22(0.75-1.98) 0.42
rs154410, VDR CC 53/235 (23 %) 29/106 (27 %) Ref -
CT/TT 182/235 (77 %) 77/106 (73 %) 1.23(0.71-2.09) 0.45
rs228570, VDR GG 137/235 (59 %) 68/107 (64 %) Ref -
GA/AA 98/235 (41 %) 39/107 (36 %) 1.89(0.80-2.10) 0.28
rs7041, DBP AA 55/232 (24 %) 21/102 (21 %) Ref -
AC/CC 177/232 (76 %) 81/102 (79 %) 0.77(0.43-1.39) 0.39
rs4588, DBP GG 122/234 (52 %) 50/107 (47 %) Ref -
GT/TT 112/234 (48 %) 57/107 (53 %) 0.93(0.58-1.49) 0.77
rs10500804, CYP2R1 GG 59/231 (26 %) 22/103 (22 %) Ref -
GT/TT 172/231 (74 %) 81/103 (78 %) 0.83(0.47-1.47) 0.53
rs2060793, CYP2R1 GG 112/228 (49 %) 51/101 (50 %) Ref -
AG/AA 116/228 (51 %) 50/101 (50 %) 0.91(0.56-1.48) 0.72
rs10766197, CYP2R1 AA 52/232 (23 %) 19/104 (18 %) Ref -
AG/GG 124/232 (77 %) 55/104 (82 %) 0.68(0.37-1.26) 0.23
  1. aOdds ratio adjusted for monthly income and vitamin D status, SNP single nucleotide polymorphism, Ref Referent category, VDR Vitamin D receptor, CYP2R1 Vitamin D 25-hydroxylase, DBP Vitamin D binding protein. The total number of samples is less than 260 and 112 in cases and controls respectively due to failed genotyping for some samples