Table 3 Association between vitamin D pathway genotype and susceptibility to active tuberculosis
SNP, gene | Genotype | TB cases, n/N (%) | TB contacts, n/N (%) | aOR (95 % CI)a | P |
|---|---|---|---|---|---|
rs7312236, VDR | AA | 84/230 (37 %) | 42/100 (42 %) | Ref | - |
AG/GG | 146/230 (63 %) | 58/100 (58 %) | 1.22(0.75-1.98) | 0.42 | |
rs154410, VDR | CC | 53/235 (23 %) | 29/106 (27 %) | Ref | - |
CT/TT | 182/235 (77 %) | 77/106 (73 %) | 1.23(0.71-2.09) | 0.45 | |
rs228570, VDR | GG | 137/235 (59 %) | 68/107 (64 %) | Ref | - |
GA/AA | 98/235 (41 %) | 39/107 (36 %) | 1.89(0.80-2.10) | 0.28 | |
rs7041, DBP | AA | 55/232 (24 %) | 21/102 (21 %) | Ref | - |
AC/CC | 177/232 (76 %) | 81/102 (79 %) | 0.77(0.43-1.39) | 0.39 | |
rs4588, DBP | GG | 122/234 (52 %) | 50/107 (47 %) | Ref | - |
GT/TT | 112/234 (48 %) | 57/107 (53 %) | 0.93(0.58-1.49) | 0.77 | |
rs10500804, CYP2R1 | GG | 59/231 (26 %) | 22/103 (22 %) | Ref | - |
GT/TT | 172/231 (74 %) | 81/103 (78 %) | 0.83(0.47-1.47) | 0.53 | |
rs2060793, CYP2R1 | GG | 112/228 (49 %) | 51/101 (50 %) | Ref | - |
AG/AA | 116/228 (51 %) | 50/101 (50 %) | 0.91(0.56-1.48) | 0.72 | |
rs10766197, CYP2R1 | AA | 52/232 (23 %) | 19/104 (18 %) | Ref | - |
AG/GG | 124/232 (77 %) | 55/104 (82 %) | 0.68(0.37-1.26) | 0.23 |