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Table 4 Association between vitamin D deficiency and host genotype, stratified by vitamin D status

From: Vitamin D deficiency associates with susceptibility to tuberculosis in Pakistan, but polymorphisms in VDR, DBP and CYP2R1 do not

SNP, gene Genotype Serum 25(OH) D ≤20 nmol/l Serum 25(OH) D >20 nmol/l   
   TB cases Controls OR(95 % CI) P TB cases Control OR(95 % CI) P Adjusted ratio of odds ratiosa P interaction
rs7312236, VDR AA 30/102(29 %) 12/24(50 %) Ref - 54/128(42 %) 30/76(40 %) Ref - Ref -
AG/GG 72/102(71 %) 12/24(50 %) 2.40(0.96-5.94) 0.054 74/128(58 %) 46/76(60 %) 0.89(0.50-1.59) 0.70 1.65(0.59-4.58) 0.33
rs154410, VDR CC 16/105(15 %) 8/25(32 %) Ref - 37/130(29 %) 21/81(26 %) Ref   Ref -
CT/TT 89/105(85 %) 17/25(68 %) 2.61(0.96-7.07) 0.052 93/130(71 %) 60/81(74 %) 0.88(0.47-1.64) 0.68 2.16(0.69-6.75) 0.18
rs228570, VDR GG 60/105(57 %) 13/25(52 %) Ref - 77/130(59 %) 55/82(67 %) Ref   Ref -
GA/AA 45/105(43 %) 12/25(48 %) 0.81(0.33-1.94) 0.64 53/130(41 %) 27/82(33 %) 1.40(0.78-2.5) 0.25 0.48(0.17-1.29) 0.14
rs10500804, CYP2R1 GG 27/102(26 %) 6/23(26 %) Ref - 32/129(25 %) 16/80(20 %) Ref   Ref -
GT/TT 75/102(74 %) 17/23(74 %) 0.98(0.35-2.74) 0.97 97/129(75 %) 64/80(80 %) 0.75(0.38-1.49) 0.42 1.51(0.47-4.8) 0.48
rs2060793, CYP2R1 GG 48/104(46 %) 11/22(50 %) Ref - 64/124(52 %) 40/79(51 %) Ref   Ref -
AG/AA 56/104(54 %) 11/22(50 %) 1.16(0.46-2.92) 0.74 60/124(48 %) 39/79(49 %) 0.96(0.54-1.69) 0.89 1.02(0.37-2.78) 0.96
rs10766197, CYP2R1 AA 23/104(22 %) 4/23(17 %) Ref - 29/128(23 %) 15/81(19 %) Ref   Ref -
AG/GG 81/104(78 %) 19/23(83 %) 0.74(0.22-2.39) 0.60 99/128(77 %) 66/81(81 %) 0.77(0.38-1.55) 0.47 1.25(0.35-4.45) 0.72
rs7041, DBP AA 27/104(52 %) 4/23(43.5 %) Ref - 26/133(20 %) 19/74(47 %) Ref   Ref -
AC/CC 77/10(35 %) 19/23(43.5 %) 0.60(0.18-1.9) 0.39 107/133(80 %) 55/74(45 %) 1.42(0.72-2.79) 0.30 1.15(0.34-3.88) 0.81
rs4588, DBP GG 55/105(52 %) 10/24(42 %) Ref - 68/135(50 %) 38/76(50 %) Ref - Ref -
GT/TT 50/105(48 %) 14/24(58 %) 0.64(0.26-1.59) 0.34 67/135(50 %) 38/76(50 %) 0.98(0.56-1.72) 0.95 0.93(0.35-2.48) 0.89
  1. aAdjusted for monthly income and vitamin D status, SNP single nucleotide polymorphism, Ref Referent category; VDR, Vitamin D receptor; CYP2R1, Vitamin D 25-hydroxylase; DBP, Vitamin D binding protein. The total number of samples is less than 260 and 112 in cases and controls respectively due to failed genotyping for some samples