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Table 1 Baseline characteristics

From: Heart rate response during 6-minute walking testing predicts outcome in operable chronic thromboembolic pulmonary hypertension

  Baseline One year post-PEA p-value
Patients, n 37  
Male/female 20/17  
Age (y) 61 ± 12  
BMI (kg/m2) 27.9 ± 5.8  
WHO functional class, (%)   b 0.7
 I none 29.6  
 II 27 48.1  
 III 62.2 22.2  
 IV 10.8 None  
6MWT    
 6MWD (m) 404.7 ± 148.4 453.4 ± 126.8 0.1
 Rest SpO2 (%) 93.9 ± 2.7 95.6 ± 2.9 0.043
 Peak SpO2 (%) 88.8 ± 5.6 92.2 ± 4.5 0.003
 Δ SpO2 (%) −5.1 ± 4.4 −3.5 ± 4.1 0.15
 Rest HR (beatsbmin-1) 83.8 ± 14.4 83.5 ± 13.9 0.98
 Peak HR (beatsbmin-1) 117.1 ± 18.8 107.8 ± 17.1 0.041
 Δ HR (beatsbmin-1) 32.6 ± 14.7 24.3 ± 12.9 0.038
 HRR (%) 45.1 ± 20.6 33.4 ± 16.7 0.022
 Δ Borg 4.4 ± 2.2 3.1 ± 2.4 0.006
 Supplemental Oxygen (n, %) 9 (24.3) 3 (8.1)b 0.33
Lung function    
 FEV1 (% pred.) 88.7 ± 13.8 88.2 ± 12.5 0.76
 FEV1/FVC (% pred.) 96 ± 10.3 90.6 ± 12.1 0.05
 TLC (% pred.) 99 ± 13.5 104.8 ± 16.8 0.11
 VC (% pred.) 91.6 ± 13.7 94 ± 12.7 0.34
RHC   
 mPAP (mm Hg) 43.2 ± 8.7 28.9 ± 10.1 0.001
 RAP (mm Hg) 5.9 ± 4.1 7.2 ± 4.3 0.15
 PVR (dynebs/cm5) 605.5 ± 228.7 328.1 ± 241.4 0.001
 CI (l/min/m2) 2.4 ± 0.5 2.7 ± 1.3 0.048
 PAWP (mm Hg) 9.5 ± 4.6 10.6 ± 4.5 0.19
Echocardiography   
 TAPSE (mm) 17.2 ± 4.3 17.5 ± 3.2 0.62
 PASP (mm Hg) 69.8 ± 25.1 56.8 ± 23.7 0.041
CPETc    
 Peak VO2 (ml/min/kg) 12.3 ± 3.4 14.2 ± 4.2 0.33
 Rest VD/VT 35.2 ± 7.6 32 ± 5.8 0.77
 Peak VD/VT 39.5 ± 8.7 35 ± 11.9 0.6
 Rest VD, L 0.35 ± 0.17 0.29 ± 0.11 0.39
 Peak VD, L 0.65 ± 0.25 0.72 ± 0.21 0.55
 Rest SpO2 (%) 94.2 ± 1.7 95.1 ± 1.4 0.10
 Peak SpO2 (%) 89.3 ± 1.4 90.7 ± 4.8 0.86
 Δ SpO2 (%) −4.9 ± 5.8 −4.4 ± 4.3 0.69
 Rest HR (beatsbmin-1) 72.8 ± 12.2 81.2 ± 11.2 0.15
 Peak HR (beatsbmin-1) 120.7 ± 21.3 122.9 ± 19.6 0.25
 Δ HR (beatsbmin-1) 47.9 ± 19.4 41.7 ± 16.3 0.72
 HRR (%) 54.7 ± 21.1 53.7 ± 20.2 0.92
Co-morbidities, n (%)   
 Hypertension 24 (64.9) Unchanged  
 Coronary heart disease 4 (10.8) Unchanged  
 Renal insuffiency 4 (10.8) Unchanged  
Jamieson-Type, %   
 I 31  
 II 31  
 III 38  
Laboratory   
 NT-proBNP (pg/ml) 488.2 [1004] 245.0 [422]a 0.006
  1. Values represent mean ± SD or median [IQR]. pred.: predicted, a = Wilcoxon Signed Rank test, b = Pearson Chi-Square test, cn = 34. CI cardiac index, mPAP mean pulmonary arterial pressure, PVR pulmonary vascular resistance, RAP right atrial pressure, PAWP pulmonary arterial wedge pressure, TAPSE tricuspid annular plane systolic excursion, PASP pulmonary artery systolic pressure, 6MWD six-minute walking distance, VO 2 oxygen uptake, WHO World Health Organization, NT-proBNP N-terminal fragment of pro-brain natriuretic peptide, V D absolute dead space, V D /V T dead space ventilation, HR heart rate, SpO 2 oxygen pulse saturation, RHC right heart catheter, CPET cardio-pulmonary exercise testing, HRR heart rate reserve, VC vital capacity, FRC functional residual capacity, TLC total lung capacity, FEV1 forced expiratory volume in 1 s