Table 3 Parameters at baseline according to exercise-induced oxygen desaturation during 6MWT

Patients, n (%)

12 (32.4)

25 (67.6)

WHO functional class, (%)

0.09

 II

33.3

24

 III

41.7

72

 IV

25

4

6MWT

 6MWD (m)

448.9 ± 206.8

383.6 ± 109.5

0.22

 Rest SpO₂ (%)

92.0 ± 2.2

94.8 ± 2.1

0.002

 Peak SpO₂ (%)

81.9 ± 4.4

92.1 ± 2.3

0.001

 Δ SpO2 (%)

10.0 ± 1.1

2.7 ± 0.4

0.02

 Rest HR (beats^amin-1)

83.5 ± 16.4

84 ± 13.7

0.9

 Peak HR (beats^amin-1)

120.6 ± 20.7

115.5 ± 18.1

0.45

 Δ HR (beats^amin-1)

30.5 ± 5.1

30.4 ± 2.4

0.82

 HRR (%)

49.5 ± 8.1

42.5 ± 4

0.53

 Δ Borg

4.7 ± 0.7

4.3 ± 0.5

0.52

 Supplemental Oxygen (n, %)

4 (33.3)

5 (20) ^a

0.38

Lung function

 FEV1 (% pred.)

83.6 ± 11.9

90.9 ± 14.1

0.15

 FEV1/FVC (% pred.)

98.6 ± 10.2

94.8 ± 10.3

0.31

 TLC (% pred.)

94.8 ± 16.3

100.8 ± 12.1

0.24

 VC (% pred.)

85.8 ± 10.3

94.1 ± 14.4

0.1

RHC

 mPAP (mm Hg)

43.8 ± 8.2

42.9 ± 9.0

0.77

 RAP (mm Hg)

4.1 ± 2.7

6.6 ± 4.4

0.8

 PVR (dyne^as/cm⁵)

640.1 ± 231.0

587.4 ± 230.5

0.53

 CI (l/min/m²)

2.5 ± 0.6

2.4 ± 0.5

0.7

 PAWP (mm Hg)

9.3 ± 2.8

9.7 ± 5.4

0.8

Echocardiography

 TAPSE (mm)

16.6 ± 4.3

17.4 ± 4.3

0.63

 PASP (mm Hg)

77.2 ± 30.7

66.2 ± 21.7

0.24

CPET^c

 Peak VO₂ (ml/min/kg)

13.1 ± 1.3

12.1 ± 0.6

0.65

 Rest V_D/V_T

33.0 ± 7.3

36.0 ± 8

0.48

 Peak V_D/V_T

39.0 ± 12.0

40.0 ± 7.3

0.78

 Rest V_D, L

0.41 ± 0.22

0.34 ± 0.14

0.4

 Peak V_D, L

0.67 ± 0.33

0.65 ± 0.23

0.9

Jamieson-Type, (%)

0.72

 I

25

32

 II

50

26

 III

25

42

Laboratory

 NT-proBNP (pg/ml)

414.0 [1260.2]

836.7 [1521]^b

0.71