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Table 2 Inflammatory markers and CT measurements by phenotype of airflow obstruction

From: Adiposity influences airway wall thickness and the asthma phenotype of HIV-associated obstructive lung disease: a cross-sectional study

 

COPD

(n = 23)

No COPD

(n = 98)

p-value

Asthmaa

(n = 33)

No asthma

(n = 88)

p-value

Sputum eosinophils >1.53 %, (n = 108)b

3 (13.6)

8 (9.3)

0.55

5 (16.1)

6 (7.8)

0.20

Sputum neutrophils (%), mean (SD)

55.9 (19.6)

50.6 (19.6)

0.27

50.0 (22.4)

52.4 (18.5)

0.57

C-reactive protein (mg/L), median (range) (n = 117)

3.4 (0-74.2)

1.1 (0-107.6)

0.04

2.3 (0-77.6)

1.1 (0-107.6)

0.04

IgE level (IU/mL) median (range) (n = 116)

33.8 (2.2-1359.0)

41.5 (0.8-2758.5)

0.60

83.9 (5.1-1447.0)

28.7 (0.8-2758.5)

0.03

Soluble CD163 (ng/mL), median (range) (n = 103)

887.9 (381.5-1999.3)

670.0 (180.1-2381.5)

0.22

726.9 (324.1-2193.1)

682.5 (180.1-2381.5)

0.11

IL-6 > median, n (%) (n = 98)

11 (64.7)

38 (46.9)

0.18

19 (67.9)

30 (42.9)

0.03

Adiponectin (ng/mL), median (range) (n = 115)

5038 (0-14590)

2822 (0-22611)

0.10

2195 (0-12663)

3713 (0-22611)

0.07

Wall area % (n = 117), mean (SD)

47.6 (4.4)

47.9 (5.7)

0.84

51.0 (4.7)

46.8 (5.3)

<0.001

SubQ adipose volume (cm3), median (range)c

22.9 (3.4-66.8)

26.8 (2.9-85.1)

0.30

33.3 (4.0-85.1)

22.1 (2.9-77.7)

0.004

Mediastinal adipose volume (cm3), median (range)c

3.3 (1.8-13.9)

4.0 (1.1-13.5)

0.40

3.9 (1.4-13.9)

4.0 (1.1-11.6)

0.33

Mediastinal/SubQ, median (range)

0.19 (0.08-0.63)

0.17 (0.04-0.62)

0.47

0.15 (0.06-0.58)

0.13 (0.04-0.63)

0.02

  1. Abbreviations: SD Standard deviation, IQR interquartile range, IL Interleukin, IFN Interferon, SubQ Subcutaneous
  2. aAsthma phenotype is defined by a history of doctor-diagnosed asthma or a bronchodilator response during pulmonary function testing
  3. bSputum eosinophil count of 1.53 % defined as the upper limit of normal
  4. cAdipose volume is standardized by dividing per 5 mm measured in the z-axis