The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia

BMC Pulmonary Medicine

Table 1 Cytokine profiles of patients with pneumonia according to severity and disease duration

	Severe pneumonia				Non-severe pneumonia				Severe x non-severe pneumonia
Cytokines (days)	Q₁	Q₃	Median	*P-value	Q₁	Q₃	Median	**P-value	***P-value
IL10 (D0)	1.50	2.68	1.99		2.44	4.05	3.68		0.074
IL10 (D3)	1.35	3.59	1.92		1.41	6.12	2.31		0.441
IL10 (D8)	1.99	5.55	2.59	0.417	1.72	11.43	2.16	0.549	1.000
IL6 (D0)	26.62	108.47	44.07		13.55	445.55	19.98		0.155
IL6 (D3)	9.27	40.48	16.45		4.95	56.34	11.13		0.959
IL6 (D8)	3.27	15.32	8.41	0.001	2.98	12.66	4.94	0.041	0.442

Note
*P-value is related to the difference in serum cytokines levels in D0, D3 and D8 for children with severe pneumonia
**P-value is related to the difference in serum cytokines levels in DO, D3 and D8 for children with non-severe pneumonia (intragroup analysis considered children with all three samples evaluated)
***P-value is related to comparisons of serum cytokine levels between group of children with severe and non-severe pneumonia in each time point D0, D3 or D8 (Intergroup analtsis considered all samples collected for each time point). Q1, first quartil, and Q3, thrird quartil. P-value ≤ 0.05 was considered significant, significant values are shown in bold

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