The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia

de Brito, Rita de Cássia Coelho Moraes; Lucena-Silva, Norma; Torres, Leuridan Cavalcante; Luna, Carlos Feitosa; Correia, Jaílson de Barros; da Silva, Giselia Alves Pontes

doi:10.1186/s12890-016-0324-z

BMC Pulmonary Medicine

Table 2 Correlation between clinical signs and blood count with cytokines serum levels of patients with severe and non-severe pneumonia

From: The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia

	IL-12p70		TNF		IL-10		IL-6		IL1β		IL-8		IFN		IL-17A		IL5		IL-6/IL-10
	r	P	r	P	r	P	r	P	r	P	r	P	r	P	r	P	r	P	r	P
Severe pneumonia
Clinical signs (days)
Abdominal pain	0.30	0.263	0.06	0.812	0.03	0.923	0.05	0.844	0.38	0.147	0.32	0.229	0.07	0.803	0.78	0.799	−0.37	0.150	0.04	0.897
Sickness	−0.03	0.906	−0.11	0.676	−0.09	0.742	0.03	0.902	−0.08	0.759	−0.12	0.661	−0.47	0.093	−0.42	0.153	−0.26	0.306	0.05	0.842
Fever	0.33	0.208	0.25	0.359	0.28	0.293	0.46	0.073	0.35	0.190	−0.13	0.644	−0.29	0.315	−0.38	0.196	−0.36	0.155	0.43	0.097
Anorexia	−0.07	0.795	−0.04	0.874	−0.24	0.374	0.30	0.263	−0.43	0.097	−0.09	0.731	−0.26	0.377	−0.19	0.530	0.08	0.766	0.31	0.238
Dyspnea	−0.03	0.905	−0.02	0.945	−0.12	0.654	0.61	0.012	0.34	0.196	0.27	0.308	−0.09	0.761	−0.2	0.523	−0.39	0.126	0.62	0.010
Subcostal recession	0.15	0.568	0.14	0.600	−0.14	0.605	0.03	0.918	0.36	0.166	−0.08	0.757	0.53	0.053	−0.15	0.615	−0.05	0.842	0.20	0.467
Difficult breathing	−0.10	0.715	0.09	0.736	−0.21	0.443	−0.05	0.862	0.09	0.738	0.23	0.388	−0.12	0.692	−0.17	0.581	0.18	0.484	−0.01	0.980
Chest pain	−0.18	0.518	0.01	0.971	−0.21	0.443	0.08	0.785	−0.12	0.676	−0.28	0.311	−0.23	0.454	−0.33	0.264	−0.03	0.912	−0.17	0.540
Coughing	−0.12	0.667	−0.02	0.532	−0.43	0.095	0.06	0.827	−0.44	0.090	−0.34	0.199	−0.39	0.165	−0.43	0.145	−0.35	0.167	0.11	0.688
Vomiting	−0.31	0.211	−0.24	0.376	0.16	0.549	0.58	0.019	−0.12	0.669	−0.08	0.761	0.22	0.447	0.28	0.362	−0.02	0.939	0.55	0.028
Blood count
Hemoglobin	−0.06	0.814	−0.18	0.517	−0.16	0.556	0.18	0.516	−0.12	0.662	−0.62	0.011	−0.03	0.919	−0.25	0.417	−0.35	0.167	0.18	0.513
Leukocytes	−0.34	0.204	−0.25	0.357	−0.11	0.674	0.51	0.045	−0.08	0.779	−0.24	0.371	0.4	0.152	0.31	0.309	−0.28	0.277	0.52	0.037
Hemacias	−0.29	0.275	−0.41	0.114	−0.15	0.57	0.08	0.757	−0.27	0.306	−0.23	0.402	−0.07	0.809	−0.05	0.866	−0.44	0.081	0.08	0.762
Neutrophils	−0.09	0.753	−0.15	0.583	−0.25	0.351	0.43	0.1	−0.32	0.228	−0.37	0.164	−0.27	0.357	−0.29	0.346	−0.21	0.419	0.44	0.088
Eosinophils	−0.07	0.805	−0.09	0.755	−0.1	0.735	−0.13	0.639	0.23	0.413	−0.48	0.069	−0.18	0.552	−0.16	0.616	0.35	0.18	−0.10	0.720
Lymphocytes	0.26	0.323	0.37	0.157	0.32	0.229	−0.33	0.218	0.45	0.084	0.46	0.071	0.32	0.268	0.31	0.307	0.4	0.114	−0.33	0.212
Monocytes	0.34	0.204	0.56	0.025	0.32	0.223	−0.29	0.282	0.52	0.04	0.26	0.332	0.16	0.587	0.07	0.819	0.02	0.954	−0.29	0.279
Platelets	0.01	0.963	0.11	0.673	−0.09	0.746	−0.21	0.431	−0.07	0.807	0.37	0.157	−0.02	0.955	0.06	0.84	0.42	0.09	−0.20	0.466
Non-severe Pneumonia
Clinical signs (days)
Abdominal pain	0.91	0.012	0.89	0.019	0.81	0.049	0.35	0.503	0.81	0.054	0.40	0.430	−0.38	0.534	−0.56	0.443	−0.38	0.406	0.34	0.514
Sickness	0.29	0.579	0.29	0.287	0.41	0.418	−0.62	0.19	−0.30	0.569	−0.54	0.273	−0.31	0.612	−0.92	0.077	0.38	0.401	−0.62	0.185
Fever	0.53	0.283	0.17	0.748	0.71	0.112	0.06	0.912	0.22	0.680	−0.06	0.909	0.11	0.856	0.10	0.897	−0.21	0.659	−0.17	0.745
Anorexia	−0.08	0.887	0.32	0.538	−0.02	0.975	0.36	0.479	0.57	0.237	0.30	0.561	−0.17	0.781	−0.28	0.722	−0.25	0.591	0.11	0.832
Dyspnea	−0.12	0.822	−0.23	0.658	0.19	0.722	−0.10	0.852	−0.18	0.739	−0.23	0.666	−0.24	0.693	−0.32	0.681	0.29	0.535	−0.11	0.837
Subcostal recession	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Difficult breathing	−0.13	0.809	0.32	0.543	−0.12	0.824	−0.19	0.371	0.18	0.739	−0.17	0.744	−0.38	0.534	−0.38	0.616	0.33	0.465	−0.20	0.707
Chest pain	-	-	-	-	-	-	-	-	-	-	-	-	−0.25	0.685	-	-	0.28	0.550	-	-
Coughing	0.31	0.555	0.38	0.454	0.43	0.400	−0.48	0.340	−0.15	0.781	−0.39	0.450	−0.48	0.417	−0.95	0.046	0.46	0.300	−0.48	0.333
Vomiting	−0.09	0.884	0.13	0.839	−0.21	0.731	1.00	<0.001	0.73	0.164	0.99	0.001	-	-	-	-	−0.58	0.229	1.00	<0.001
Blood count
Hemoglobin	0.62	0.189	0.24	0.641	0.54	0.27	0.3	0.57	0.42	0.402	0.23	0.66	0.97	0.006	0.97	0.031	−0.82	0.024	0.29	0.575
Leukocytes	−0.55	0.256	−0.35	0.496	−0.68	0.138	0.49	0.328	0.16	0.765	0.44	0.387	0.54	0.348	0.72	0.282	−0.48	0.273	0.49	0.319
Hemacias	−0.45	0.371	−0.56	0.251	−0.65	0.166	0.29	0.571	−0.23	0.666	0.31	0.552	0.71	0.178	0.74	0.256	−0.49	0.268	0.31	0.551
Neutrophils	−0.64	0.172	−0.21	0.688	−0.76	0.078	0.49	0.321	0.2	0.699	0.5	0.311	−0.01	0.987	0.1	0.9	−0.18	0.707	0.50	0.313
Eosinophils	0.49	0.325	0.19	0.714	0.71	0.113	−0.38	0.455	−0.13	0.813	−0.43	0.399	−0.31	0.61	−0.4	0.597	0.33	0.467	−0.39	0.440
Lymphocytes	0.73	0.097	0.47	0.346	0.87	0.025	−0.48	0.333	−0.01	0.986	−0.47	0.345	−0.45	0.443	−0.62	0.379	0.3	0.516	−0.49	0.320
Monocytes	0.08	0.888	−0.24	0.646	0.36	0.483	−0.44	0.386	−0.39	0.448	−0.56	0.247	0.02	0.98	−0.09	0.913	0.23	0.623	−0.45	0.374
Platelets	−0.42	0.411	−0.4	0.438	−0.34	0.506	−0.48	0.338	−0.71	0.115	−0.4	0.43	−0.39	0.519	−0.56	0.439	0.7	0.08	−0.47	0.346

Note: r, Person correlation. P-value <0.05 was considered significant, significant values are shown in bold

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