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Table 3 Interleukin (IL)-6 and the IL-6:IL-10 serum levels ratio as marker of pneumonia severity and recovery

From: The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia

IL-6 IL-6/IL-10
Time-points Severe pneumonia Non-severe pneumonia   CI 95% Time-points Severe pneumonia Non-severe pneumonia   CI 95%
At admission    Sen = 76.5 49.8 – 92.2 At admission    Sen = 76.5 49.8 – 92.2
 >21.1 13 1 Spec = 83.3 36.5 – 99.1 >9.61 13 1 Spec = 83.3 36.5 – 99.1
 ≤21.1 4 5 PPV = 92.9 64.2 – 99.6 ≤9.61 4 5 PPV = 92.9 64.2 – 99.6
    NPV = 55.6 22.7 – 84.7     NPV = 55.6 22.7 – 84.7
D3    Sen = 58.3 28.6 – 83.5 D3    Sen = 72.7 39.3 – 92.7
 >11.28 7 2 Spec = 60.0 17.0 – 92.7 >5.00 8 1 Spec = 80.0 29.9 – 98.9
 ≤11.28 5 3 PPV = 77.8 40.2 – 96.1 ≤5.00 3 4 PPV = 88.9 50.7 – 99.4
    NPV = 37.5 10.2 – 74.1     NPV = 57.1 20.2 – 88.2
D8      D8     
 >5.07 8 2 Sen = 66.7 35.4 – 88.7 >2.40 7 1 Sen = 63.6 31.6 – 87.6
 ≤5.07 4 3 Spec = 60.0 17.0 – 92.7 ≤2.40 4 4 Spec = 80.0 29.9 – 98.9
    PPV = 80.0 44.2 – 96.5     PPV = 87.5 46.7 – 99.3
    NPV = 42.9 11.8 – 79.8     NPV = 50.0 17.4 – 82.6
  1. Note: D0 day of admission, D3 third day and D8 - eighth day of hospitalization, Sen sensitivity, Spec specificity, PPV positive predictive value, NPV negative predictive value, CI confidence interval