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Table 3 Clinical symptoms and physical findings related to IPAF and anti-synthetase syndrome

From: Long-term clinical course of anti-glycyl tRNA synthetase (anti-EJ) antibody-related interstitial lung disease pathologically proven by surgical lung biopsy

Patient number

Diagnosis

Cough

Dyspnea

Mechanic’s hand, Gottron’s sign

Heliotrope rash

Raynaud’s phenomenon

Articular involvementa

Unexplained digital oedema

Unexplained fever

Muscular involvementb

Distal digital tip ulceration

CK level

1

IPAF/ASS

+

-

-

-

-

-

-

-

-

-

218

2

IPAF/ASS

+

+

-

-

-

+

-

-

-

-

136

3

IPAF/ASS

+

-

-

-

-

-

-

-

-

-

50

4

PMI

+

-

-

-

-

+c

-

-

+c

-

346E

5

IPAF/ASS

+

+

-

-

-

-

-

+c

+c

-

51

6

DMI

+

-

+

-

+c

-

-

+c

-

-

143

7

IPAF/ASS

+

+

-

-

-

-

-

+c

+c

-

17

8

PMI

+

-

+c

-

+c

+c

+c

-

-

-

513E

9

DMI

-

+

+c

-

+c

+c

-

-

+c

-

137

10

IPAF/ASS

+

+

-

-

-

-

-

+

+c

-

22

11

PMI

+

+

-

-

-

+

+

-

+c

-

230

12

PMS

+

+

-

-

-

-

-

+

+

-

672E

  1. ainflammatory arthritis, or polyarticular morning joint stiffness > 60mins, bproximal muscular weakness, or myalgia, CK: creatine kinase, IPAF: interstitial pneumonia with autoimmune features, ASS: anti-synthetase syndrome, PM: polymyositis, DM: dermatomyositis, I: interstitial lung disease preceded PM/DM, S: simultaneous onset of PM and interstitial lung disease, csymptoms occurred during follow up, E: The CK level is greater than reference value