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Table 2 Inflammatory markers across four symptom classes

From: Symptom profiles and inflammatory markers in moderate to severe COPD

 

Mean (95% CI) for Total Sample

Class 1

Low-Phys/Low-Psych

Class 2

Low-Phys/Mod-Psych

Class 3

High-Phys/Mod-Psych

Class 4

High-Phys/High-Psych

P Value

Variables

n = 302

(n = 80)

(n = 55)

(n = 77)

(n = 90)

 

Interleukin-1 (IL-1), pg/mL

0.6 (0.2,1.5)

18 (23%)

16 (29%)

19 (25%)

25 (28%)

0.80

Interleukin-2 (IL-2), pg/mL

2.7 (1.0,7.1)

18 (23%)

18 (33%)

20 (26%)

22 (24%)

0.59

Interleukin-4 (IL-4), pg/mL

17.3 (7.1, 42.3)

22 (28%)

15 (27%)

16 (21%)

25 (28%)

0.71

Interleukin-5 (IL-5), pg/mL

0.9 (0.4,1.9)

20 (25%)

13 (24%)

18 (23%)

26 (29%)

0.84

Interleukin-6 (IL-6), pg/mL

2.9 (1.8, 5.0)

22 (28%)

16 (29%)

23 (30%)

16 (18%)

0.25

Interleukin-7 (IL-7), pg/mL

2.4 (1.1, 4.7)

29 (36%)

12 (22%)

17 (22%)

19 (21%)

0.08

Interleuken-8 (IL-8), pg/mL

3.7 (2.7, 5.7)

27 (34%)

17 (31%)

17 (22%)

17 (19%)

0.10

Interleukin-10 (IL-10), pg/mL

18.3 (10.5, 37.4)

24 (30%)

14 (25%)

18 (23%)

21 (23%)

0.74

Interleukin-12 (IL-12), pg/mL

3.9 (1.8, 8.4)

22 (28%)

17 (31%)

15 (19%)

23 (26%)

0.48

Interleukin-13 (IL-13), pg/mL

0.5 (0.1, 3.9)

20 (25%)

18 (33%)

20 (26%)

20 (22%)

0.57

Interferon (IFN), pg/mL

9.2 (4.1, 21.0)

19 (24%)

17 (31%)

16 (21%)

25 (28%)

0.55

Granulocyte macrophage-colony stimulating factor (GM-CSF), pg/mL

2.8 (1.3, 6.9)

20 (25%)

17 (31%)

17 (22%)

23 (26%)

0.72

Tumor necrosis factor

(TNF-α), pg/mL

4.7 (3.3, 6.8)

25 (31%)

14 (25%)

21 (27%)

17 (19%)

0.31

High sensitivity C-reactive protein (CRP), mg/L

3.2 (1.5, 6.0)

42 (52%)

33 (60%)

23 (31%)

43 (48%)

0.005†∫∞

  1. Values for the total sample are presented as median (IQR); by symptom class, n (%) > 75th percentile or % of patients with CRP > 3 mg/L. Phys = Physical Symptoms; Psych = Psychological Symptoms; Mod: Moderate. Post-hoc pairwise contrasts, p < .05: †Class 1 vs. Class 3, ∫Class 2 vs. Class 3, ∞Class 3 vs. Class 4