B-type natriuretic peptides in chronic obstructive pulmonary disease: a systematic review

BMC Pulmonary Medicine

Table 4 Accuracy of natriuretic peptides in predicting left ventricular systolic dysfunction

	n	Population	%LVSD (LVEF)	Threshold	Left ventricular dysfunction	NPV	PPV
Rutten [24]	200	primary care elderly	15 (≤45%)	BNP 35 pg/ml NT-BNP 125 pg/ml	panel adjudicated systolic dysfunction	~0.95	~0.4
Abroug [46]	148	intensive care unit	18 (<50%)	NT-BNP 1000 pg/ml	panel adjudicated systolic or diastolic dysfunction	0.94	0.78
Gariani [47]	57	hospitalization retrospective	23 (<50%)	BNP 500 pg/ml	systolic dysfunction diastolic dysfunction	0.88 0.80	0.47 0.41
Wang [32]	311	hospitalization	16 (<45%)	NT–BNP 935 pg/ml	panel adjudicated systolic or diastolic dysfunction	0.98	0.47

BNP B-type natriuretic peptide; LVEF left ventricular ejection fraction; LVSD left ventricular systolic dysfunction; NPV negative predictive value; NT-proBNP N-terminal proBNP; PPV positive predictive value

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