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Table 6 Risk of bias domains assessed

From: B-type natriuretic peptides in chronic obstructive pulmonary disease: a systematic review

Selection

Is there consecutive or random participant sampling?

Misclassification

Are key inclusion/exclusion criteria clearly stated and defined by valid and reliable measures?

Performance

Did the study vary from the protocol proposed by the investigators, and was there appropriate ethical approval?

Detection

Is the study design prospective, retrospective, or mixed?

Reporting

Are important primary outcomes missing from the results?

Information

Were valid and reliable measures used consistently across all study participants to assess outcomes, exposures or interventions?

Confounding Interpretation

Were important confounding and effect modifying variables accounted for in the design and/or analysis?