Skip to main content
Fig. 5 | BMC Pulmonary Medicine

Fig. 5

From: Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis

Fig. 5

MMP7 network analysis from RNA-Seq (FFPE) and microarrays (FF) data independently. All differentially expressed genes from RNA-Seq (4,131) and from microarrays (5,859) were submitted to MetaCore to build and draw the network around MMP7 gene, a common network gene for both datasets. Increased genes were marked in yellow and decreased genes were marked in purple for both datasets (RNA-Seq (a), and microarrays (b)). Gene homologues that have mixed expression values were marked with yellow/purple*. The rest of the genes that are present in network but are not detected in our datasets, belong to a pre-build network for MMP7 in MetaCore database. Canonical pathways identified in network are marked in light blue. Red arrows represent inhibitory effect between two genes in the network and green arrows represent activation effect. Function of each network gene is defined by different shape and explained in the figure legend. *Please note yellow/purple colors were manually added, instead of red/blue originally proposed by MetaCore, to keep consistent gene expression visualization through the manuscript

Back to article page