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Table 2 Change From Baselinea in 6MWD at Week 12 (LOCF) Williams Trend Test

From: Efficacy of 1, 5, and 20 mg oral sildenafil in the treatment of adults with pulmonary arterial hypertension: a randomized, double-blind study with open-label extension

Value

Sildenafil Dose, TID

1 mg (n = 41)

5 mg (n = 43)

20 mg (n = 45)

Least squares mean

14.21

40.75

38.36

MLE meanb

14.21

39.52

39.52

Mean differencec

24.15

−1.17

—

Williams statistic

2.37

−0.11

—

97.5% lower confidence limit

3.37

−21.48

—

P valued

0.011

0.545

—

  1. 6MWD 6-minute walk distance, LOCF last observation carried forward, MLE maximum likelihood estimation, TID 3 times daily
  2. aBaseline is the average of the screening and day 1 values
  3. bMLE mean is defined as least squares mean if it satisfies descending response relationship for descending doses; if descending relationship does not hold, MLE mean is defined as weighted mean of adjacent least squares means
  4. cMean difference was calculated as the least squares mean for sildenafil 20 mg minus the MLE mean for sildenafil lower dose
  5. dFrom directional test vs 20 mg TID
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BMC Pulmonary Medicine

ISSN: 1471-2466

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