IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation

Table 2 Relationship between Interleukin-8 (IL-8) and risk of 28-day mortality

IL-8 on admission vs 28 days follow-up death (Model 1 and 2)
	Continuous IL-8 analysis (per SD increment)	P-value	Tertile 1	Tertile 2	Tertile 3	P for trend
N/N events^b	46/13		15/1	16/3	15/9
HR (95% CI) (age and gender adjusted)	3.88 (1.86–8.06)	<0.001	1.0 (ref)	2.79 (0.29–26.89)	10.02 (1.24–80.77)	0.009
HR (95% CI) (age, gender and CRP adjusted)^a	3.76 (2.02–7.03)	<0.001	1.0 (ref)	3.11 (0.32–29.93)	13.47 (1.70–106.91)	0.003

SD standard deviation, HR hazard ratio, CI confidence interval, CRP C-reactive protein
^aBackward elimination model
^bdeath within 28 days from admission

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