IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation

Table 4 Relationship between IL-8/GDF-15 and risk of 28-day mortality in a subgroup of patients with AECOPD

IL-8 and GDF-15 on admission vs 28 days follow-up death – AECOPD subgroup
	IL-8		GDF-15
	Continuous analysis (per SD increment)	P-value	Continuous analysis (per SD increment)	P-value
N/N events^b	34/11		34/11
HR (95% CI) (age and gender adjusted)	4.16 (1.84–9.39)	0.001	3.10 (1.30–7.40)	0.011
HR (95% CI) (age, gender and CRP adjusted)^a	4.34 (2.05–9.19)	<0.001	3.28 (1.56–6.88)	0.002

AECOPD acute exacerbation of COPD, SD standard deviation, HR hazard ratio, CI confidence interval, CRP C-reactive protein
^aBackward elimination model
^bdeath within 28 days from admission

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