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Table 2 Baseline characteristics of patients categorised as GOLD A and B

From: Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients

  GOLD A (n = 34) GOLD B (n = 107) p value
Demographics
 Gender (% Male) 58.8 67.3 0.41
 Pack years 44.5 [10.0–135.0] 45 [10.0–220.0] 0.53
 Smoking status (% Current) 15.2 36.5 0.031
 BMI (Kg/m2) 26.1 [20.6–47.0] 27.2 [16.5–49.2] 0.73
 FFMI (Kg/m2) 17.3 [12.9–28.7] 17.6 [10.0–27.0] 0.92
 Chronic bronchitis (%) 21.2 57.4 0.0003
 Exacerbations (1 year prior) 0.0 [0.0–1.0] 0.0 [0.0–1.0] 0.11
Co-morbidities
 Cardiovascular comorbidity any (%) 61.8 82.2 0.019
 Comorbidities any (%) 35.3 16.8 0.03
Patient reported outcomes
 SGRQ total 19.3 [1.0–40.0] 40.9 [5.7–82.4] <0.0001
 SGRQ symptoms 29.5 (16.5) 55.3 (17.8) <0.0001
 SGRQ impact 12.0 [3.0–24.0] 25.0 [0.0–75.5] <0.0001
 SGRQ activity 34.8 (18.5) 58.9 (22.6) <0.0001
 CAT 6.0 [2.0–9.0] 16.0 [4.0–39.0] <0.0001
 CES-D 5.0 [1.0–6.0] 11.5 [1.0–4.0] <0.0001
Functional capacity
 6MWD (metres) 457.0 [169.0–636.0] 405.7 [119.0–702.0] 0.07
Lung function
 Vital capacity % 102.3 (22.5) 100.7 (17.9) 0.73
 Total lung capacity % 108.9 (16.1) 109.2 (20.1) 0.96
 Residual volume % 130.6 [89.1–179.9] 132.0 [63.0–286.0] 0.90
 Inspiratory capacity % 87.1 (23.0) 89.5 (21.3) 0.65
 FRC % 125.8 (24.0) 128.7 (33.2) 0.71
 DLCO % 70.8 [56.0–116.5] 63.0 [28.0–106.0] 0.05
 KCO % 86.8 [64.0–126.5] 76.4 [35.0–137.0] 0.13
 VA % 84.2 (13.3) 80.8 (10.7) 0.25
 Post FEV1 % 71.0 (15.2) 68.3 (11.4) 0.27
 Reversibility % 9.8 [4.0–16.0] 6.7 [−3.0–+38.0] 0.13
 Reversibility mls 150.0 [−40.0–+290.0] 100.0 [−80.0–+670.0] 0.21
Bacteriology
 Bacterial load (genome copies/ml) 7.11 × 106 [0–1.81 × 1010] 7.74 × 104 [0–4.91 × 108] 0.29
 Colonised (% >1 × 104 total PPM) 63.7 55.6 0.75
Systemic inflammation
 CRP (mg/L) 3.0 [1.0–22.0] 3.0 [1.0–157.0] 0.35
 WBC (109/L) 6.8 [3.6–12.0] 7.3 [5.0–12.6] 0.11
 Eosinophils (109/L) 0.2 [0.0–0.8] 0.2 [0.0–0.9] 0.83
  1. Summaries are presented as mean (SD), percentage or Median [Range] as appropriate
  2. Definitions of abbreviations: BMI body mass index, FFMI fat free mass index, SGRQ St George’s Respiratory Questionnaire, CAT COPD Assessment Test, CES-D Centre for Epidemiologic Studies Depression, 6MWD six minute walk distance, FRC functional residual capacity, DLCO diffusing capacity of the lungs for carbon monoxide, KCO carbon monoxide transfer coefficient, VA alveolar volume, CRP C-reactive protein, WBC white blood count, PPM potentially pathogenic microorganism