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Table 3 Comparison of 1 year characteristics of patients who remained stable (GOLD B) and unstable patients (GOLD D) from baseline

From: Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients

 

GOLD B (n = 51)

GOLD D (n = 19)

p - value

Demographics

 Gender (% Male)

75.6

52.6

0.15

 BMI (Kg/m2)

27.0 [16.2–44.8]

27.7 [21.7–48.5]

0.32

 FFMI (Kg/m2)

18.3 [8.8–24.0]

17.6 [11.7–27.0]

0.75

 Exacerbations (1 year prior)

0.0 [0.0–1.0]

2.0 [0.0–4.0]

<0.0001

Patient reported outcomes

 SGRQ total

41.1 (15.5)

50.0 [22.2–82.3]

0.001

 SGRQ symptoms

54.6 (19.9)

61.0 (17.5)

0.24

 SGRQ impact

26.3 [2.1–71.6]

42.4 [4.6–60.1]

0.05

 SGRQ activity

59.3 [0.0–100.0]

78.1 [22.5–100.0]

0.003

 CAT

15.5 [9.0–35.0]

20.0 [9.0–37.0]

0.018

 CES-D

12.0 [0.0–33.0]

15.0 [0.0–31.0]

0.58

Functional capacity

 6MWD (metres)

440.5 (125.7)

347.3 (123.4)

0.023

Lung function

 Vital capacity %

99.2 (21.9)

93.6 (13.1)

0.40

 Total lung capacity %

110.2 (17.0)

110.5 (23.5)

0.96

 Residual volume %

132.0 (30.4)

150.0 (55.9)

0.16

 Inspiratory capacity %

93.1 (21.8)

91.4 (20.9)

0.81

 FRC %

125.6 (25.7)

132.5 (45.9)

0.52

 DLCO %

56.5 [40.0–102.0]

61.5 [32.0–115.0]

0.87

 KCO %

75.5 (80.1)

74.7 (85.0)

0.53

 VA %

81.4 (13.1)

76.9 (14.2)

0.29

 Post FEV1 %

68.2 (12.3)

57.3 (12.8)

0.002

 Reversibility %

−4.4 [−53.8–+8.0]

−8.1 [17.3–+8.3]

0.25

 Reversibility mls

20.0 [−170.0–580]

90 [−120–200]

0.90

 Change in FEV1 from baseline

−80.0 [−420.0–+939.0]

−120.0 [−531.0–+180.0]

0.07

Bacteriology

 Bacterial load (genome copies/ml)

2.36 × 106 [0–8.89 × 108]

10.3 × 107 [0–1.76 × 108]

0.25

 Colonised (% >1 × 104 total PPM)

71.4

77.2

1.00

Systemic inflammation

 CRP (mg/L)

3.0 [1.0–20.0]

5.0 [2.0–20.0]

0.017

 WBC (109/L)

6.9 [3.6–13.5]

7.5 [4.8–11.8]

0.73

 Eosinophils (109/L)

0.2 [0.1–0.6]

0.2 [0.0–0.4]

0.24

  1. Summaries are presented as mean (SD), percentage or Median [Range] as appropriate
  2. Definitions of abbreviations: BMI body mass index, FFMI fat free mass index, SGRQ St George’s Respiratory Questionnaire, CAT COPD assessment test, CES-D Centre for Epidemiologic Studies Depression, 6MWD six minute walk distance, FRC functional residual capacity, DLCO diffusing capacity of the lungs for carbon monoxide, KCO carbon monoxide transfer coefficient, VA alveolar volume, CRP C-reactive protein, WBC white blood count, PPM potentially pathogenic microorganisms