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Table 3 Comparison of 1 year characteristics of patients who remained stable (GOLD B) and unstable patients (GOLD D) from baseline

From: Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients

  GOLD B (n = 51) GOLD D (n = 19) p - value
Demographics
 Gender (% Male) 75.6 52.6 0.15
 BMI (Kg/m2) 27.0 [16.2–44.8] 27.7 [21.7–48.5] 0.32
 FFMI (Kg/m2) 18.3 [8.8–24.0] 17.6 [11.7–27.0] 0.75
 Exacerbations (1 year prior) 0.0 [0.0–1.0] 2.0 [0.0–4.0] <0.0001
Patient reported outcomes
 SGRQ total 41.1 (15.5) 50.0 [22.2–82.3] 0.001
 SGRQ symptoms 54.6 (19.9) 61.0 (17.5) 0.24
 SGRQ impact 26.3 [2.1–71.6] 42.4 [4.6–60.1] 0.05
 SGRQ activity 59.3 [0.0–100.0] 78.1 [22.5–100.0] 0.003
 CAT 15.5 [9.0–35.0] 20.0 [9.0–37.0] 0.018
 CES-D 12.0 [0.0–33.0] 15.0 [0.0–31.0] 0.58
Functional capacity
 6MWD (metres) 440.5 (125.7) 347.3 (123.4) 0.023
Lung function
 Vital capacity % 99.2 (21.9) 93.6 (13.1) 0.40
 Total lung capacity % 110.2 (17.0) 110.5 (23.5) 0.96
 Residual volume % 132.0 (30.4) 150.0 (55.9) 0.16
 Inspiratory capacity % 93.1 (21.8) 91.4 (20.9) 0.81
 FRC % 125.6 (25.7) 132.5 (45.9) 0.52
 DLCO % 56.5 [40.0–102.0] 61.5 [32.0–115.0] 0.87
 KCO % 75.5 (80.1) 74.7 (85.0) 0.53
 VA % 81.4 (13.1) 76.9 (14.2) 0.29
 Post FEV1 % 68.2 (12.3) 57.3 (12.8) 0.002
 Reversibility % −4.4 [−53.8–+8.0] −8.1 [17.3–+8.3] 0.25
 Reversibility mls 20.0 [−170.0–580] 90 [−120–200] 0.90
 Change in FEV1 from baseline −80.0 [−420.0–+939.0] −120.0 [−531.0–+180.0] 0.07
Bacteriology
 Bacterial load (genome copies/ml) 2.36 × 106 [0–8.89 × 108] 10.3 × 107 [0–1.76 × 108] 0.25
 Colonised (% >1 × 104 total PPM) 71.4 77.2 1.00
Systemic inflammation
 CRP (mg/L) 3.0 [1.0–20.0] 5.0 [2.0–20.0] 0.017
 WBC (109/L) 6.9 [3.6–13.5] 7.5 [4.8–11.8] 0.73
 Eosinophils (109/L) 0.2 [0.1–0.6] 0.2 [0.0–0.4] 0.24
  1. Summaries are presented as mean (SD), percentage or Median [Range] as appropriate
  2. Definitions of abbreviations: BMI body mass index, FFMI fat free mass index, SGRQ St George’s Respiratory Questionnaire, CAT COPD assessment test, CES-D Centre for Epidemiologic Studies Depression, 6MWD six minute walk distance, FRC functional residual capacity, DLCO diffusing capacity of the lungs for carbon monoxide, KCO carbon monoxide transfer coefficient, VA alveolar volume, CRP C-reactive protein, WBC white blood count, PPM potentially pathogenic microorganisms