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Table 4 Baseline characteristics of patients who remained stable (GOLD B) and unstable patients (GOLD D) at 1 year

From: Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients

 

Stable (n = 51)

Unstable (n = 19)

p - value

Demographics

 Gender (% Male)

72.5

52.6

0.15

 Pack years

45.0 [10.0–220.0]

52.0 [10.0–113.0]

0.67

 Smoking status (% Current)

37.3

36.8

1.00

 BMI (Kg/m2)

27.2 [17.3–49.2]

27.9 [20.7–45.0]

0.28

 FFMI (Kg/m2)

17.8 (3.4)

18.7 (3.4)

0.34

 Chronic bronchitis (%)

58.3

61.1

1.00

 Exacerbations (1 year prior)

0.0 [0.0–1.0]

0.0 [0.0–1.0]

0.88

Co-morbidities

 Cardiovascular comorbidity any (%)

94.1

94.7

1.00

 Comorbidities any (%)

94.1

94.7

1.00

Patient reported outcomes

 SGRQ total

40.1 [14.6–80.0]

50.0 [22.2–82.3]

0.019

 SGRQ symptoms

55.1 [22.0–91.0]

60.8 [15.4–90.0]

0.10

 SGRQ impact

26.0 [2.5–71.6]

35.9 [9.0–73.7]

0.20

 SGRQ activity

59.3 [7.6–100.0]

79.0 [15.6–100.0]

0.003

 CAT

14.0 [4.0–28.0]

21.0 [8.0–39.0]

0.006

 CES-D

11.0 [1.0–32.0]

12.5 [3.0–38.0]

0.94

Functional capacity

 6MWD (metres)

425.3 (98.5)

361.5 (124.8)

0.06

Lung function

 Vital capacity %

103.3 (19.8)

96.6 (16.5)

0.25

 Total lung capacity %

108.8 (19.9)

111.8 (24.6)

0.65

 Residual volume %

130.9 (37.4)

150.4 (60.2)

0.16

 Inspiratory capacity %

87.0 (23.0)

89.8 (16.1)

0.67

 FRC %

129.3 (30.7)

134.2 (44.5)

0.65

 DLCO %

66.2 (20.3)

64.1 (24.3)

0.76

 KCO %

75.5 [41.2–137.0]

81.5 [35.0–124.0]

0.97

 VA %

82.8 (12.0)

79.2 (9.3)

0.32

 Post FEV1 %

69.7 (11.7)

62.4 (9.0)

0.016

 Reversibility %

5.0 [−3.0–+33.0]

7.4 [0.8–32.0]

0.47

 Reversibility mls

90.0 [−40.0–+670.0]

95.0 [20.0–+380.0]

0.90

Bacteriology

 Bacterial load (genome copies/ml)

1.44 × 105 [0.0–2.43 × 108]

7.4 × 102 [0–10.4 × 107]

0.66

 Colonised (% >1 × 104 total PPM)

66.7

46.2

0.30

Systemic inflammation

 CRP (mg/L)

3.0 [1.0–35.5]

4.5 [1.0–157.0]

0.06

 WBC (109/L)

7.2 [5.4–12.6]

7.4 [5.0–12.6]

0.42

 Eosinophils (109/L)

0.2 [0.0–0.9]

0.2 [0.1–0.3]

0.32

  1. Summaries are presented as mean (SD), percentage or Median [Range] as appropriate
  2. Definitions of abbreviations: BMI body mass index, FFMI fat free mass index, SGRQ St George’s Respiratory Questionnaire, CAT COPD Assessment Test, CES-D Centre for Epidemiologic Studies Depression, 6MWD six minute walk distance, FRC functional residual capacity, DLCO diffusing capacity of the lungs for carbon monoxide, KCO carbon monoxide transfer coefficient, VA alveolar volume, CRP C-reactive protein, WBC white blood count, PPM potentially pathogenic microorganisms