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Table 2 Diagnostic procedures and treatment of group 3 PH patients and control patients

From: Healthcare burden of pulmonary hypertension owing to lung disease and/or hypoxia

 

Baseline

Follow-up

Group 3 PH

(n = 2236)

Controls

(n = 2236)

Group 3 PH

(n = 2236)

Controls

(n = 2236)

Diagnostic procedures

 Echocardiography

1679 (75.1)

518 (23.2)

1678 (75.0)

441 (19.7)

 Stress echocardiography

313 (14.0)

176 (7.9)

212 (9.5)

150 (6.7)

 Other radiography

107 (4.8)

77 (3.4)

79 (3.5)

59 (2.6)

 Electrocardiography

1779 (79.6)

1264 (56.5)

1777 (79.5)

1160 (51.9)

 Computerized tomography

1001 (44.8)

693 (31.0)

1030 (46.1)

567 (25.4)

 Angiography

385 (17.2)

187 (8.4)

385 (17.2)

122 (5.5)

 RHC

144 (6.4)

15 (0.7)

135 (6.0)

6 (0.3)

 MRI

39 (1.7)

17(0.8)

52 (2.3)

29 (1.3)

 Other exercise testing

452 (20.2)

89 (4.0)

574 (25.7)

84 (3.8)

Therapeutic treatment

 Vena cava procedure

0

0

19 (0.9)

2 (0.09)

 Ventilation perfusion

76 (3.4)

12 (0.5)

58 (2.6)

2 (0.09)

 Oxygen therapy

1 (0.04)

1 (0.04)

3 (0.1)

2 (0.09)

Pharmacotherapy

366 (16.4)

33 (1.5)

495 (22.1)

41 (1.8)

 Oral anticoagulants

704 (31.5)

442 (19.8)

853 (38.2)

456 (20.4)

 Diuretics

1273 (56.9)

714 (31.9)

1447 (64.7)

722 (32.3)

 Calcium channel blockers

800 (35.8)

624 (27.9)

853 (38.2)

621 (27.8)

 Digoxin

200 (9.0)

85 (3.8)

249 (11.1)

91 (4.1)

 PAH-approved pharmaceuticalsa

366 (16.4)

33 (1.5)

495 (22.1)

41 (1.8)

  Prostacyclin analogues

19 (0.9)

0

34 (1.5)

0

   ERAs

182 (8.1)

0

226 (10.1)

0

   PDE5 inhibitorsb

279 (12.5)

33 (1.5)

394 (17.6)

41 (1.8)

  1. Values are expressed as No. (%)
  2. ERA endothelin receptor antagonist, MRI magnetic resonance imaging, PDE5 phosphodiesterase type-5, PH pulmonary hypertension, RHC right heart catheterization
  3. aIncludes unique patients with ≥1 pharmaceutical claim for prostacyclin analogues, endothelin receptor antagonists, and/or PDE5 inhibitors
  4. bPDE5 inhibitors include those indicated for pulmonary arterial hypertension (PAH), as well as those for other indications or used off-label