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Table 3 Key diagnostic procedures and PH-related pharmaceutical claims during follow-up by underlying lung disease

From: Healthcare burden of pulmonary hypertension owing to lung disease and/or hypoxia

Therapy

Comorbid COPD

Comorbid ILD

Comorbid SDB

Comorbid DLD

Group 3 PH

(n = 1590)

Controls

(n = 1590)

Group 3 PH

(n = 438)

Controls

(n = 438)

Group 3 PH

(n = 340)

Controls

(n = 340)

Group 3 PH

(n = 503)

Controls

(n = 502)

Diagnostic Procedure

 Echocardiography

1181 (74.3)

313 (19.7)

340 (77.6)

85 (19.4)

252 (74.1)

66(19.4)

374 (74.4)

124 (24.7)

 RHC

92 (5.8)

2 (0.1)

32 (7.3)

4 (0.9)

16 (4.7)

2 (0.6)

32 (6.4)

2 (0.4)

Pharmaceutical Treatment

 Oral anticoagulants

642 (40.3)

331 (20.8)

137 (31.3)

75 (17.1)

122 (35.9)

81 (23.8)

197 (39.2)

138 (27.5)

 Diuretics

1084 (68.2)

521 (32.8)

236 (53.9)

126 (28.8)

224 (65.9)

134 (39.4)

359 (71.4)

185 (36.9)

 Calcium channel blockers

600 (37.7)

428 (26.9)

172 (39.3)

147 (33.6)

138 (40.6)

105 (30.9)

214 (42.5)

154 (30.7)

 Digoxin

194 (12.2)

67 (4.2)

46 (10.5)

17 (3.9)

22 (6.5)

13 (3.8)

64 (12.7)

23 (4.6)

 Prostacyclin analogues

22 (1.4)

0

15 (3.4)

0

4 (1.2)

0

7 (1.4)

0

 ERAs

137 (8.6)

0

102 (23.3)

0

25 (7.4)

0

32 (6.4)

0

 PDE5 inhibitorsa

255 (16.0)

25 (1.6)

136 (31.1)

6 (1.4)

39 (1.7)

17 (0.8)

74 (14.7)

6 (1.2)

  1. Data are given as No. (%). Follow-up refers to the 12-month period after the index date
  2. COPD chronic obstructive pulmonary disease, DLD developmental lung diseases, ERA endothelin receptor antagonist, ILD interstitial lung disease, PDE5 phosphodiesterase type-5, RHC right heart catheterization, SDB sleep disorder breathing
  3. aPDE5 inhibitors potentially include those indicated for pulmonary arterial hypertension (PAH), for other indications, or used off-label