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Table 4 Annual resource utilization and direct costs

From: Healthcare burden of pulmonary hypertension owing to lung disease and/or hypoxia

Type

Group 3 PH

Controls

Unadjusted DID (95% CI)

Adjusted DID (95% CI)

P value

Baseline

Follow-up

Difference

Baseline

Follow-up

Difference

All-cause utilization, n

 Inpatient admissions

3.7 (8.0)

6.2 (11.4)

2.5 (10.6)

2.5 (6.1)

2.2 (5.9)

−0.2 (6.0)

2.7 (2.2–3.2)

3.1 (2.6–3.7)

<.0001

 Outpatient visits

17.6 (22.3)

24.6 (27.8)

7.0 (21.7)

9.2 (12.6)

9.6 (15.4)

0.4 (11.7)

6.6 (5.6–7.6)

6.5 (5.5–7.6)

<.0001

 Physician office visits

18.6 (14.2)

20.3 (15.0)

1.7 (12.1)

14.3 (12.6)

13.6 (12.7)

−0.8 (10.0)

2.5 (1.8–3.1)

2.8 (2.1–3.5)

<.0001

 ED visits

0.8 (2.1)

0.9 (2.3)

0.2 (1.8)

0.4 (0.9)

0.5 (1.1)

0.1 (1.2)

0.1 (0.02–0.20)

0.1 (0.05–0.2)

0.002

 Prescription claims

78.3 (50.3)

86.1 (50.7)

7.8 (31.0)

58.8 (43.7)

61.0 (45.1)

2.2 (21.2)

5.6 (3.9–6.9)

6.1 (4.5–7.7)

<.0001

All-cause costs, US$

 Total

34,040 (71,571)

44,732 (104,621)

10,691 (89,617)

8102 (14,108)

7051 (12,887)

−1051 (15,432)

11,743 (7972–15,513)

10,240 (6266–14,214)

<.0001

 Inpatient

11,485 (51,815)

15,852 (84,677)

4367 (81,147)

1764 (8963)

1015 (4668)

−749 (9548)

5116 (1728–8503)

4280 (706–7855)

.019

 Outpatient

8429 (28,357)

11,875 (34,344)

3446 (23,809)

2171 (5804)

1908 (8281)

−263 (8736)

3709 (2657–4760)

3309 (2198–4421)

<.0001

 Physician office

1655 (3599)

1825 (4948)

170 (4105)

853 (2285)

816 (3001)

−37 (2290)

207 (12–402)

238 (31–444)

.024

 ED

372 (1916)

385 (1894)

13 (1497)

79 (389)

113 (1471)

35 (1495)

−22 (−110–66)

−36 (−130–56)

.44

 Prescription

12,099 (27,938)

14,795 (29,228)

2696 (18,807)

3235 (4622)

3198 (4,371)

−37 (2412)

2733 (1947–3519)

2449 (1616–3282)

<.0001

  1. Values are expressed as mean (SD) unless otherwise specified. Baseline and follow-up refer to the 12-month periods pre- and post-index date, respectively
  2. “Physician office” refers to outpatient physician office visits; “outpatient” refers to all other outpatient services. ED visits that led to hospitalization were counted as both an ED visit and an inpatient visit
  3. Costs were inflated to 2013 US $ and rounded to closest dollar. Costs reflect fully paid and adjudicated medical claims paid by a third party payer. DID of healthcare costs and utilizations between the two groups from baseline to follow-up time period were analyzed by using GEE regression models adjusting for age, sex, census region, health plan type, and CCI. P < .05 was considered statistically significant
  4. CI confidence interval, DID difference-in-difference, ED emergency department, SD standard deviation