Electromagnetic navigation bronchoscopy to access lung lesions in 1,000 subjects: first results of the prospective, multicenter NAVIGATE study

Table 4 Lung lesion characteristics (subjects undergoing ENB- aided biopsy)

	N = 1129 Lesions in 964 Subjects
Pre-test probability of malignancy (physician estimation)	67.1 ± 26.5 (790) [75.0] (0.0–100.0)
Pre-test probability of malignancy (Swenson’s equation)^a	61.6 ± 29.4 (789) [67.1] (2.9–100.0)
Average Lung Lesion Size, mm
Mean ± SD (N)	23.6 ± 14.4 (1129)
Median, Range (min-max)	20.0 (3.0–118.0)
Interquartile Range (Q1-Q3)	16.0 (14.0–30.0)
< 20 mm	49.7% (561/1129)
≥ 20 mm	50.3% (568/1129)
Lesion Location
Right Upper Lobe	31.7% (358/1129)
Right Middle Lobe	8.1% (91/1129)
Right Lower Lobe	19.0% (215/1129)
Left Upper Lobe	25.9% (292/1129)
Left Lower Lobe	15.3% (173/1129)
Lung Zone^b
Peripheral third of lung on CT	62.6% (707/1129)
Middle third of lung on CT	30.1% (340/1129)
Proximal third of lung on CT	7.3% (82/1129)
Lesion Visible on Fluoroscopy	60.0% (610/1017)
Ground Glass Lesions (Suzuki Class 1 or 2) [28]	6.3% (71/1123)
Spiculated Lesion Border	60.9% (687/1128)
Bronchus Sign Present on CT	48.4% (546/1129)
Lesion PET Positive (≥2.5 standard uptake value)	80.9% (479/592)

Data are presented as n/N (%) or mean ± standard deviation (n) [median] (range)
Acronyms: CT computed tomography, PET positron emission tomography, SD standard deviation
^aPre-test probability of malignancy (calculated): x = −6.8272 + (0.0391 * “age”) + (0.7917 * “tobacco history”) + (1.3388 * “history of extrathoracic cancer”) + (0.1274 * “diameter in mm”) + (1.0407 * “spiculation”) + (0.7838 * “upper lobe”). Not applicable to patients with a diagnosis of cancer that has been made within the previous 5 years or to patients with previous lung cancer [29]
^bSee Folch et al. 2016 for definitions [7]

ISSN: 1471-2466