Table 3 Risk of a subsequent exacerbation of patients with ≥1 exacerbation during the 12-month after a previous exacerbation

Exacerbation type

OCS only

Ref.

Ref.

ED/hospitalization

1.35 (1.26, 1.44)

1.32 (1.18, 1.47)^*

Exacerbations during the 12-month pre-index period

0

NR

Ref.

≥1

NR

1.90 (1.75, 2.05)^*

GINA (US only) or BTS (UK only) Treatment Steps^c

Step 1

Steps 1–3 combined: Ref.

Ref.

Step 2

1.02 (0.90, 1.17)

Step 3

1.35 (1.19, 1.53)^*

Step 4

1.26 (1.18, 1.35)

1.44 (1.25, 1.65)^*

Step 5

1.44 (1.32, 1.56)

1.87 (1.64, 2.14)^*

Not classifiable/none

0.76 (0.34, 1.69)

1.36 (0.85, 2.19)