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Table 3 Patient demographics, pulmonary function indices, CALIPER and visually scored CT parameters and echocardiography data in 2 groups of chronic hypersensitivity pneumonitis patients. Group 1 had an IPF-like outcome (n = 20) and group 2 had a good outcome (n = 96). Differences between groups were assessed using the T-test for continuous variables, the Mann Whitney U test for differences in continuous median values and the Chi-Squared test for categorical variables. CT = computed tomography, FEV1 = forced expiratory volume in one second, FVC = forced vital capacity, DLco = diffusing capacity for carbon monoxide, Kco = carbon monoxide transfer coefficient, TLC = total lung capacity, CPI = composite physiological index, ILD = interstitial lung disease, RVSP = right ventricular systolic pressure TxBx = traction bronchiectasis, PA = pulmonary artery. Comparison of hypersensitivity pneumonitis patients groups: IPF-like versus non-IPF-like outcome

From: Chronic hypersensitivity pneumonitis: identification of key prognostic determinants using automated CT analysis

Variable
Units are percentage unless stated
Group 1
(n = 20 unless stated in brackets)
Group 2
(n = 96 unless stated in brackets)
Group Differences
Median Age (years) 56 · 5 59 NS
Male/female 7/13 32/64 NS
Survival (alive/dead) 6/14 71/25 <0 · 0001
Never/ever/current smokers 15/4/0 (19) 56/38/2 NS
Pack years 28 · 5 ± 26 · 5 16 · 4 ± 14 · 9 NS
FEV1 % predicted 48 · 1 ± 12 · 1 (18) 72 · 5 ± 18 · 4 (94) <0 · 0001
FVC % predicted 45 · 6 ± 10 · 8 (18) 77 · 3 ± 20 · 9 (94) <0 · 0001
DLco % predicted 28 · 1 ± 8 · 4 (16) 45 · 5 ± 15 · 4 (93) <0 · 0001
Kco % predicted 70 · 4 ± 16 · 4 (16) 70 · 1 ± 16 · 3 (93) NS
TLC% predicted 50 · 9 ± 7 · 2 (14) 75 · 3 ± 15 · 4 (89) <0 · 0001
CPI 64 · 6 ± 6 · 5 (16) 45 · 0 ± 14 · 3 (92) <0 · 0001
Echocardiography RVSP (mmHg) 33 · 0 ± 6 · 5 (8) 35 · 4 ± 15 · 9 (50) NS
CALIPER ILD extent 58 · 6 ± 17 · 2 17 · 2 ± 15 · 9 <0 · 0001
CALIPER Ground glass opacity 48 · 7 ± 21 · 1 13 · 5 ± 14 · 9 <0 · 0001
CALIPER Reticular pattern 9 · 4 ± 5 · 1 3 · 4 ± 2 · 5 <0 · 0001
CALIPER Honeycombing 0 · 5 ± 1 · 1 0 · 3 ± 0 · 4 NS
CALIPER Emphysema 0 · 2 ± 0 · 4 0 · 5 ± 1 · 8 NS
CALIPER Pulmonary vessel volume 7 · 7 ± 0v8 3 · 8 ± 1 · 3 <0 · 0001
Visual ILD extent 74 · 9 ± 17 · 4 59 · 5 ± 25 · 1 =0 · 002
Visual Ground glass opacity 24 · 1 ± 13 · 5 35 · 3 ± 25 · 3 =0.006
Visual Reticular pattern 44 · 4 ± 14 · 7 22 · 7 ± 16 · 6 <0 · 0001
Visual Honeycombing 3 · 6 ± 9 · 5 0 · 4 ± 1 · 1 NS
Visual Emphysema 0 · 3 ± 0 · 5 3 · 5 ± 9 · 2 =0 · 001
Visual TxBx severity (max score 18) 9 · 2 ± 4 · 9 5 · 2 ± 4 · 4 =0 · 0004
Main PA diameter (mm) 31 · 5 ± 4 · 5 29 · 2 ± 4 · 9 NS
Ascending aorta diameter (mm) 32 · 2 ± 4 · 3 33 · 3 ± 3 · 9 NS
PA:ascending aorta ratio 1.0 ± 0.2 0.9 ± 0.1 =0.006