Table 3 Patient demographics, pulmonary function indices, CALIPER and visually scored CT parameters and echocardiography data in 2 groups of chronic hypersensitivity pneumonitis patients. Group 1 had an IPF-like outcome (n = 20) and group 2 had a good outcome (n = 96). Differences between groups were assessed using the T-test for continuous variables, the Mann Whitney U test for differences in continuous median values and the Chi-Squared test for categorical variables. CT = computed tomography, FEV1 = forced expiratory volume in one second, FVC = forced vital capacity, DLco = diffusing capacity for carbon monoxide, Kco = carbon monoxide transfer coefficient, TLC = total lung capacity, CPI = composite physiological index, ILD = interstitial lung disease, RVSP = right ventricular systolic pressure TxBx = traction bronchiectasis, PA = pulmonary artery. Comparison of hypersensitivity pneumonitis patients groups: IPF-like versus non-IPF-like outcome

Median Age (years)

56 · 5

59

NS

Male/female

7/13

32/64

NS

Survival (alive/dead)

6/14

71/25

<0 · 0001

Never/ever/current smokers

15/4/0 (19)

56/38/2

NS

Pack years

28 · 5 ± 26 · 5

16 · 4 ± 14 · 9

NS

FEV1 % predicted

48 · 1 ± 12 · 1 (18)

72 · 5 ± 18 · 4 (94)

<0 · 0001

FVC % predicted

45 · 6 ± 10 · 8 (18)

77 · 3 ± 20 · 9 (94)

<0 · 0001

DLco % predicted

28 · 1 ± 8 · 4 (16)

45 · 5 ± 15 · 4 (93)

<0 · 0001

Kco % predicted

70 · 4 ± 16 · 4 (16)

70 · 1 ± 16 · 3 (93)

NS

TLC% predicted

50 · 9 ± 7 · 2 (14)

75 · 3 ± 15 · 4 (89)

<0 · 0001

CPI

64 · 6 ± 6 · 5 (16)

45 · 0 ± 14 · 3 (92)

<0 · 0001

Echocardiography RVSP (mmHg)

33 · 0 ± 6 · 5 (8)

35 · 4 ± 15 · 9 (50)

NS

CALIPER ILD extent

58 · 6 ± 17 · 2

17 · 2 ± 15 · 9

<0 · 0001

CALIPER Ground glass opacity

48 · 7 ± 21 · 1

13 · 5 ± 14 · 9

<0 · 0001

CALIPER Reticular pattern

9 · 4 ± 5 · 1

3 · 4 ± 2 · 5

<0 · 0001

CALIPER Honeycombing

0 · 5 ± 1 · 1

0 · 3 ± 0 · 4

NS

CALIPER Emphysema

0 · 2 ± 0 · 4

0 · 5 ± 1 · 8

NS

CALIPER Pulmonary vessel volume

7 · 7 ± 0v8

3 · 8 ± 1 · 3

<0 · 0001

Visual ILD extent

74 · 9 ± 17 · 4

59 · 5 ± 25 · 1

=0 · 002

Visual Ground glass opacity

24 · 1 ± 13 · 5

35 · 3 ± 25 · 3

=0.006

Visual Reticular pattern

44 · 4 ± 14 · 7

22 · 7 ± 16 · 6

<0 · 0001

Visual Honeycombing

3 · 6 ± 9 · 5

0 · 4 ± 1 · 1

NS

Visual Emphysema

0 · 3 ± 0 · 5

3 · 5 ± 9 · 2

=0 · 001

Visual TxBx severity (max score 18)

9 · 2 ± 4 · 9

5 · 2 ± 4 · 4

=0 · 0004

Main PA diameter (mm)

31 · 5 ± 4 · 5

29 · 2 ± 4 · 9

NS

Ascending aorta diameter (mm)

32 · 2 ± 4 · 3

33 · 3 ± 3 · 9

NS

PA:ascending aorta ratio

1.0 ± 0.2

0.9 ± 0.1

=0.006