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Table 3 Univariate analysis for 60-day mortality

From: Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center study

 

HR

95% CI

p value

Age

1.02

0.98–1.05

0.31

Male sex

0.74

0.38–1.45

0.38

IPF diagnosis

   

Possible UIP with traction bronchiectasis

1

0.36–2.80

0.99

Surgical lung biopsy, Yes

1.08

0.52–2.26

0.83

HRCT pattern of AE

   

Multifocal

0.41

0.10–1.71

0.22

Corticosteroid use before admission

0.75

0.41–1.38

0.38

Immunosuppressant before admission

1.19

0.60–2.36

0.62

Antifibrotic drug before admission

1.11

0.51–2.38

0.80

Anticoagulant drug before admission

1.40

0.50–3.91

0.52

APACHE II score

1.12

1.03–1.21

0.008

PaO2/FiO2

0.99

0.99–1

0.04

Lactate dehydrogenase (IU/L)

1

1.001–1.006

0.002

C-reactive protein (mg/dl)

1.05

1.0–1.1

0.04

KL-6 (U/ml)

1

0.99–1

0.49

Surfactant protein D (ng/ml), n = 75

1

0.99–1

0.23

Invasive mechanical ventilation

2.34

0.92–5.98–3.52

0.07

Noninvasive mechanical ventilation

1.85

1.01–3.37

0.047

High flow nasal cannula

0.53

0.07–3.89

0.54

Combination beta lactam

0.74

0.29–1.87

0.53

Azithromycin use

0.28

0.14–0.57

<0.001

  1. Abbreviations: IPF idiopathic pulmonary fibrosis, UIP usual interstitial pneumonia, HRCT high-resolution computed tomography, AE acute exacerbation, APACHE II Acute Physiology and Chronic Health Evaluation II