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Table 3 Longitudinal changes in lung function, exercise capacity and physical activity in survivors

From: Prognosis and longitudinal changes of physical activity in idiopathic pulmonary fibrosis

Characteristic

Absolute value at baseline

Absolute value at follow-up

Absolute decline (Baseline to follow-up)

Relative decline (Baseline to follow-up)

Average annual decline

p-value

FVC, liter

3.05 (0.81)

2.64 (0.78)

−0.41 (0.33)

13.3%

−0.13 (0.11)

<0.001

FVC, %pred.

84.8 (22.9)

76.1 (23.9)

−8.7 (9.6)

10.5%

−2.8 (3.0)

<0.001

DLCO, %pred.

50.7 (13.6)

43.5 (18.4)

−7.3 (13.3)

14.4%

−2.2 (4.2)

0.024

6MWD, meters

418 (117)

389 (132)

−29 (64)

7.8%

−8.8 (20)

0.055

Steps per day

6499 (3192)

3482 (2350)

−3017 (2372)

48.3%

−973 (743)

<0.001

  1. Data are presented as mean (SD) and % for n = 23 survivors with complete physical activity data at follow-up. Differences between baseline and follow-up visit were tested by paired t-tests. Follow-up data were missing for FVC (n = 1), DLCO (n = 3), and 6MWD (n = 2)
  2. Abbreviations: FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, 6MWD 6-min walking-distance