Bivariate | Multivariate | ||||||
---|---|---|---|---|---|---|---|
Variable | Category | Coef | 95% CI | P-value | Coef | 95% CI | P-value |
Time | Per each month since Tx | 0.16 | 0.10 to 0.22 | <0.001 | 0.18 | 0.12 to 0.24 | <0.001 |
CLAD | RAS | −6.60 | −11.594 to-1.603 | 0.01 | −5.19 | −10.2 to −0.16 | 0.04 |
BOS | −8.14 | −11.807 to −4.473 | <0.001 | −6.51 | −10.26 to −2.77 | 0.001 | |
BOS grade | 0p | −2.05 | −4.165 to 0.069 | 0.06 | |||
1 | −2.53 | −5.122 to 0.068 | 0.06 | ||||
2 | −6.49 | −9.724 to −3.261 | <0.001 | ||||
3 | −4.90 | −8.731 to −1.066 | 0.01 | ||||
Lymphocytic population | cd3 | 0.009 | 0.008 to 0.01 | <0.001 | |||
cd 3 cd4 | 0.021 | 0.019 to 0.023 | <0.001 | ||||
cd 3 cd8 | 0.01 | 0.008 to 0.011 | <0.001 | ||||
cd19 | 0.05 | 0.038 to 0.057 | <0.001 | ||||
cd1 6 cd56 | 0.01 | 0.005 to 0.008 | <0.001 | ||||
cd4cd25high | 0.60 | 0.585 to 0.62 | <0.001 | ||||
Immunosuppressive therapy | Cyclosporine | 0.20 | −3.598 to 4.007 | 0.92 | |||
Tacrolimus | −2.71 | −5.783 to 0.367 | 0.08 | ||||
Azathioprine | 4.65 | 0.438 to 8.856 | 0.03 | −2.12 | −6.73 to 2.48 | 0.336 | |
Mycophenolate | 0.04 | −1.735 to 1.823 | 0.96 | ||||
Rapamycin | −0.75 | −3.202 to 1.703 | 0.55 | ||||
Prednisone | −6.32 | −15.329 to 2.687 | 0.17 | ||||
Azithromycin therapy | −0.74 | −2.505 to 1.016 | 0.41 | 0.58 | −1.28 to 2.43 | 0.542 | |
Extracorporeal photopheresis | −6.03 | −8.259 to −3.804 | <0.001 | −5.65 | −8.05 to −3.25 | <0.001 | |
Kidney failure | −1.36 | −3.62 to 0.907 | 0.24 |