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Table 1 Demographic and clinical characteristics of young children with cystic fibrosis by pathogen acquisition status, 2003–2009

From: Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis

 

Respiratory Pathogen

MSSA

MRSA

S. maltophilia

A. xylosoxidans

Acquired (n = 1885)

Negative (n = 1127)

P value

Acquired (n = 706)

Negative (n = 3405)

P value

Acquired (n = 992)

Negative (n = 3144)

P value

Acquired (n = 201)

Negative (n = 4054)

P value

Male (%)

909 (48)

589 (52)

0.04

347 (49)

1731 (51)

0.44

502 (51)

1581 (50)

0.89

86 (43)

2061 (51)

0.03

White (%)

1750 (93)

1019 (90)

0.02

636 (90)

3134 (92)

0.10

913 (92)

2887 (92)

0.88

179 (89)

3726 (92)

0.19

Hispanic (%)

201 (11)

121 (11)

0.99

50 (7)

403 (12)

<0.01

124 (13)

327 (10)

0.07

35 (17)

430 (11)

<0.01

Any Private Insurance (%)

984 (52)

591 (52)

0.93

301 (43)

1903 (56)

<0.01

471 (47)

1721 (55)

<0.01

79 (39)

2174 (54)

<0.01

Age at diagnosis, months, mean (SD)

2.5 (4.3)

2.2 (4.3)

0.12

2.7 (4.3)

2.3 (4.2)

0.66

2.5 (4.2)

2.4 (4.3)

0.26

3.2 (4.8)

2.4 (4.2)

0.03

Identified by newborn screening (%)

663 (35)

611 (54)

<0.01

213 (30)

1555 (46)

<0.01

358 (36)

1414 (45)

<0.01

68 (34)

1756 (43)

<0.01

CFTR functional classa (%)

 Severe

1275 (68)

714 (63)

0.04

514 (73)

2148 (63)

<0.01

695 (70)

1991 (63)

<0.01

134 (67)

2638 (65)

0.03

 Residual

156 (8)

116 (10)

 

45 (6)

328 (10)

 

60 (6)

315 (10)

 

8 (4)

373 (9)

 

 Unclassified

454 (24)

297 (26)

 

147 (21)

929 (27)

 

237 (24)

838 (27)

 

59 (29)

1043 (26)

 
  1. Data given as No. (%) unless otherwise indicated, MSSA methicillin susceptible Staphylococcus aureus, MRSA methicillin resistant Staphylococcus aureus, S maltophilia, Stenotrophomonas maltophilia, A. xylosoxidans, Achromobacter xylosoxidans
  2. a CFTR Mutation class is defined as follows: Severe, includes children in which both CFTR allele mutations result in minimal CFTR function (class 1, 2, or 3), including F508 del; Residual, children for which at least one allele with a mutation resulting in partial CFTR function is present (class 4 or 5); Unclassified, both alleles with unknown functional class, or one allele with minimal CFTR function and the second with unknown functional class