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Table 1 Clinical, radiographic and physiologic characteristics of study participants stratified by hrct pattern

From: Serological and morphological prognostic factors in patients with interstitial pneumonia with autoimmune features

  

HRCT pattern

 

total

OP

NSIP + OP

NSIP

p value

Number of patients, n

98

20 (20.4%)

15 (15.3%)

63 (64.3%)

 

Age, yr

67.5 [59.0, 76.0]

68.5 [64.8, 73.8]

67.0 [52.5, 76.0]

68.0 [59.0, 76.0]

0.88

Male gender, n (%)

41 (41.8%)

10 (50.0%)

6 (40.0%)

25 (39.7%)

0.693

Smoking

 never smokers, n

60 (61.2%)

12 (60%)

11 (73.3%)

37 (58.7%)

0.653

 former/current smoker, n

38 (38.8%)

8 (40%)

4 (26.7%)

26 (41.3%)

 

Onset

 subacute, n (%)

36 (36.3%)

20 (100%)

14 (93.3%)

2 (3.2%)

<0.001

 chronic, n (%)

62 (63.3%)

0(0%)

1 (6.7%)

61 (96.8%)

 

Laboratory data

 WBC,103/m m3

6900 [5725, 900]

775 [6500, 10,325]

8900 [6000, 9700]

6500 [5600, 7650]

0.03

 CRP,g/dL

0.46 [0.14, 1.92]

7.60 [3.25, 11.59]

1.03 [0.50, 1.81]

0.25 [0.11, 0.59]

<0.001

 KL6,U/ml

945 [552, 1673]

321[280, 337]

1172 [887, 3049]

1135 [771, 1775]

<0.001

Pulmonary function %predicted

n = 85

n = 11

n = 13

n = 61

 

 FVC, %predicted

76.3 [62.7, 88.6]

81.2 [72.1, 87.9]

50.9 [42.1, 65.2]

54.8 [46.2, 71.9]

0.2

 DLCO, %predicted

56.6 [46.4, 76.3]

82.9 [75.6, 100.6]

67.9 [57.1, 87.1]

75.6 [62.7, 88.0]

0.009

BAL fluid

n = 75

n = 16

n = 12

n = 47

 

 Lymphocytes, %

19.0 [10.0,39.0]

53.0 [27.5, 71.3]

34.9 [16.2, 48.5]

13.0 [8.5, 24.1]

<0.001

 Neutrophils, %

6.0 [1.9,12.5]

7.5 [1.8, 14.6]

9.7 [5.1, 16.3]

4.0 [1.2, 10.5]

0.225

 Eosinophils, %

1.7 [0.9,4.7]

2.0 [1.0, 12.0]

3.7 [1.4, 5.0]

1.0 [0.3, 3.3]

0.177

Autoantibodies, n

 SSc-specific and SSc-reralted antibodies, n

36

3

2

31

 

 Nucleolar-ANA, n

15

0

0

15

 

 Anti-Centromere, n

4

1

0

3

 

 Anti-RNP, n

9

2

1

6

 

 Anti-Scl-70, n

8

0

1

7

 

 Anti-CCP, n

15

3

2

10

 

 Anti-Jo1, n

9

2

3

4

 

 ARS Ab other than anti-Jo1, n

4

0

3

1

 

 Anti-La/SSB, n

7

1

4

3

 

 ANA (≧1:320), n

28

1

4

23

 

 Rheumatoid factor (>60 IU/ml), n

28

8

3

17

 

 Anti-Ro/SSA, n

18

6

3

9

 

 Anti-dsDNA, n

6

1

2

3

 

 Anri-Sm, n

4

1

0

3

 
  1. Some patients had multiple serological tests. Data are presented as No. (%), median(range). ANA antinuclear antibody, Anti-CCP uclic anti-citrullinated peptide, Anti-dsDNA anti-double stranded DNA, Anti-RNP anti ribonucleoprotein, ARS Ab anti-tRNA synthetase antibodies, Anti-Scl-70 anti-Sclero 70, BAL bronchoalveolar lavage, CRP C reactive protein, DLCO diffusing capacity of the lung for carbon monoxide, FVC forced vital capacity, IPAF Interstitial pneumonia with autoimmune features, NSIP non-specific interstitial pneumonia, NSIP + OP NSIP with OP overlap, OP organizing penumonia, SScAb SSc-related antibody