HRCT pattern | |||||
---|---|---|---|---|---|
total | OP | NSIP + OP | NSIP | p value | |
Number of patients, n | 98 | 20 (20.4%) | 15 (15.3%) | 63 (64.3%) | |
Age, yr | 67.5 [59.0, 76.0] | 68.5 [64.8, 73.8] | 67.0 [52.5, 76.0] | 68.0 [59.0, 76.0] | 0.88 |
Male gender, n (%) | 41 (41.8%) | 10 (50.0%) | 6 (40.0%) | 25 (39.7%) | 0.693 |
Smoking | |||||
 never smokers, n | 60 (61.2%) | 12 (60%) | 11 (73.3%) | 37 (58.7%) | 0.653 |
 former/current smoker, n | 38 (38.8%) | 8 (40%) | 4 (26.7%) | 26 (41.3%) | |
Onset | |||||
 subacute, n (%) | 36 (36.3%) | 20 (100%) | 14 (93.3%) | 2 (3.2%) | <0.001 |
 chronic, n (%) | 62 (63.3%) | 0(0%) | 1 (6.7%) | 61 (96.8%) | |
Laboratory data | |||||
 WBC,103/m m3 | 6900 [5725, 900] | 775 [6500, 10,325] | 8900 [6000, 9700] | 6500 [5600, 7650] | 0.03 |
 CRP,g/dL | 0.46 [0.14, 1.92] | 7.60 [3.25, 11.59] | 1.03 [0.50, 1.81] | 0.25 [0.11, 0.59] | <0.001 |
 KL6,U/ml | 945 [552, 1673] | 321[280, 337] | 1172 [887, 3049] | 1135 [771, 1775] | <0.001 |
Pulmonary function %predicted | n = 85 | n = 11 | n = 13 | n = 61 | |
 FVC, %predicted | 76.3 [62.7, 88.6] | 81.2 [72.1, 87.9] | 50.9 [42.1, 65.2] | 54.8 [46.2, 71.9] | 0.2 |
 DLCO, %predicted | 56.6 [46.4, 76.3] | 82.9 [75.6, 100.6] | 67.9 [57.1, 87.1] | 75.6 [62.7, 88.0] | 0.009 |
BAL fluid | n = 75 | n = 16 | n = 12 | n = 47 | |
 Lymphocytes, % | 19.0 [10.0,39.0] | 53.0 [27.5, 71.3] | 34.9 [16.2, 48.5] | 13.0 [8.5, 24.1] | <0.001 |
 Neutrophils, % | 6.0 [1.9,12.5] | 7.5 [1.8, 14.6] | 9.7 [5.1, 16.3] | 4.0 [1.2, 10.5] | 0.225 |
 Eosinophils, % | 1.7 [0.9,4.7] | 2.0 [1.0, 12.0] | 3.7 [1.4, 5.0] | 1.0 [0.3, 3.3] | 0.177 |
Autoantibodies, n | |||||
 SSc-specific and SSc-reralted antibodies, n | 36 | 3 | 2 | 31 | |
 Nucleolar-ANA, n | 15 | 0 | 0 | 15 | |
 Anti-Centromere, n | 4 | 1 | 0 | 3 | |
 Anti-RNP, n | 9 | 2 | 1 | 6 | |
 Anti-Scl-70, n | 8 | 0 | 1 | 7 | |
 Anti-CCP, n | 15 | 3 | 2 | 10 | |
 Anti-Jo1, n | 9 | 2 | 3 | 4 | |
 ARS Ab other than anti-Jo1, n | 4 | 0 | 3 | 1 | |
 Anti-La/SSB, n | 7 | 1 | 4 | 3 | |
 ANA (≧1:320), n | 28 | 1 | 4 | 23 | |
 Rheumatoid factor (>60 IU/ml), n | 28 | 8 | 3 | 17 | |
 Anti-Ro/SSA, n | 18 | 6 | 3 | 9 | |
 Anti-dsDNA, n | 6 | 1 | 2 | 3 | |
 Anri-Sm, n | 4 | 1 | 0 | 3 |