Table 2 Adjusted mean levels of FEV1 by quartile of inflammatory biomarkers and associations per IQR change

Q1

(0.07–0.99)

Q2

(1.00–2.41)

Q3

(2.42–6.91)

Q4

(6.92–161.56)

p-for trend

β (95% CI) mL FEV1 per 5.91 mg/L CRP

p-value

77

78

78

78

311

311

311

3.05 (2.89, 3.22)

2.84 (2.68, 3.00)

2.59 (2.43, 2.75)

2.55 (2.39, 2.71)

0.0002

−63.71 (−99.27,-28.15)

0.0005

2.93 (2.76, 3.10)

2.82 (2.67, 2.97)

2.66 (2.51, 2.82)

2.62 (2.46, 2.78)

0.0346

−55.85 (−89.21,-22.49)

0.0012

2.93 (2.77, 3.09)

2.81 (2.66, 2.96)

2.67 (2.52, 2.82)

2.62 (2.47, 2.77)

0.0183

−51.83 (−83.92,-19.74)

0.0017

Q1

(0.30–1.26)

Q2

(1.27–2.12)

Q3

(2.13–4.44)

Q4

(4.45–46.8)

p-for trend

β (95% CI) mL FEV1 per 3.18 pg/mL IL-6

p-value

77

83

76

75

311

311

311

2.98 (2.81, 3.15)

2.82 (2.66, 2.98)

2.71 (2.54, 2.88)

2.51 (2.34, 2.68)

0.0003

−101.28 (−156.74,-45.83)

0.0004

2.90 (2.74, 3.07)

2.75 (2.60, 2.90)

2.77 (2.61, 2.92)

2.61 (2.44, 2.77)

0.0388

−61.39 (−115.47,-7.30)

0.027

2.90 (2.75, 3.06)

2.75 (2.60, 2.89)

2.77 (2.61, 2.92)

2.61 (2.45, 2.76)

0.0240

−61.48 (−112.64,-10.33)

0.0192