Unmet needs in the treatment of idiopathic pulmonary fibrosis―insights from patient chart review in five European countries

Table 4 Disease characteristics

Factor, n (%)	Treated N = 828	Untreated N = 909
Diagnostic values
FVC
FVC > 80%	94 (11.4)	163 (17.9)^**
FVC 71–80%	143 (17.3)	183 (20.1)
FVC 50–70%	425 (51.3)	335 (36.9)^**
FVC < 50%	102 (12.3)	122 (13.4)
FVC not tested	64 (7.7)	106 (11.7)^**
DLco
DLco < 35%	74 (8.9)	85 (9.4)
DLco ≥ 35%	634 (76.6)	612 (67.3)^**
DLco not tested	121 (14.6)	212 (23.3)^**
6MWD
6MWD < 150 m	71 (8.6)	71 (7.8)
6MWD ≥ 150 m	460 (55.6)	323 (35.5)^**
Not tested	297 (35.9)	516 (56.8)^**
Last visit
Mild IPF (current level)	149 (18.0)	370 (40.7)^**
FVC
FVC > 80%	39 (4.7)	119 (13.1)^**
FVC 71–80%	116 (14.0)	134 (14.7)
FVC 50–70%	427 (51.6)	279 (30.7)^**
FVC < 50%	148 (17.9)	141 (15.5)
FVC not tested	98 (11.8)	236 (26.0)^**
Evolution in severity level^a from diagnosis to last check-up
Improvement	38 (4.6)	36 (4.0)
Stable	637 (76.9)	782 (86.0)^**
Worsening	154 (18.6)	92 (10.1)^**
Type of progression
Stable IPF	259 (31.3)	463 (50.9)^**
Slow progressing	383 (46.3)	291 (32.0)^**
Progressive	159 (19.2)	114 (12.5)^**
Fast progressing	27 (3.3)	41 (4.5)

For individual questions asked, please refer to Additional file 2
6MWD 6-min walk distance, DLco carbon monoxide diffusing capacity, FVC forced vital capacity, IPF idiopathic pulmonary fibrosis
^aEvolution in severity levels was defined as follows: Improvement = from Moderate to Mild/from Severe to Moderate or Mild; Stable = unchanged level of severity at diagnosis to last check-up; Worsening = from Mild to Moderate or Severe/from Moderate to Severe
p values represent treated population versus untreated population. ^* p ≤ 0.05; ^** p ≤ 0.01

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