Fig. 2
Comparison of DEGs of each patient cluster revealed genes commonly dysregulated in IPF and genes associated with severe lung function decline. DEG were divided into six groups based on the number of patient clusters where a gene was differentially expressed. Panel a shows schematic representation of 2968 DEG in six IPF patient clusters. DEGs along with their group designation are shown in the same order along the outer rim of each circular plot. The center of each circular represents patient cluster with the color intensity representing average % predicted DLCO in that cluster. Each colored edge (red: up-regulated; green: down-regulated) from a patient cluster to a gene in the rim indicates differential expression of that gene in the connected patient cluster. Panel b is a heat map representation of the 2968 DEG. Up- or down- regulated genes in each group that are involved or implicated in IPF were highlighted