Fig. 3

Enriched biological processes in each gene category revealed commonly and high-severity-associated biological pathways perturbed in IPF. Selected enrichment terms derived from gene lists in DEG groups were shown. Connection from a gene (rectangular node) to a biological process (purple oval node) indicates involvement of that gene in the connected process. Differential expression status of a gene in each patient subgroup was shown as a mini heat map (orange: up-regulation; turquoise: down-regulation; gray: not differentially expressed, patient subgroup order: C1, C2, C3, C4, C5 and C6). Network was made in Cytoscape 3.5, and layout was performed using AllegroLayout v2 Professional with manual curation