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Table 1 Characteristics of the patients analyzed in the study

From: A rise in mean platelet volume during hospitalization for community-acquired pneumonia predicts poor prognosis: a retrospective observational cohort study

Characteristics

Entire sample (n = 976)

Group A No rising MPV ΔMPV < 0.6 fL (n = 818)

Group B Rising MPV ΔMPV ≥ 0.6 fL (n = 158)

Difference between groups A and B p-value

 Age (years)

64.6 ± 21

63.4 ± 20

70.7 ± 21

< 0.001

 Male sex

52.3%

51.2%

57.6%

0.1

Comorbid conditions

 Renal dysfunction

33.6%

31.3%

45.6%

< 0.001

 Diabetes mellitus

30.9%

31.4%

28.5%

0.5

 Coronary artery disease

24.2%

23.5%

27.8%

0.2

 Chronic lung disease

28.1%

27.0%

33.5%

0.1

 Heart failure

16.8%

15.8%

22.2%

0.06

 Cerebrovascular disease

16.9%

15.2%

25.9%

0.001

 History of malignancy

8.4%

8.2%

9.5%

0.6

 Acute bleeding during hospitalization/blood transfusion

3.3%/6.0%

2.9%/5.7%

5.1%/7.6%

0.5/0.4

 Pleural effusion/bilateral lung involvement

25.8%/16.0%

25.8%/15.5%

25.9%/18.4%

1.0/0.4

 CURB-65 class

1.78 ± 1.0

1.71 ± 1.0

2.15 ± 1.1

< 0.001

 Pneumonia Severity Index score/risk class

100.1 ± 45/3.44 ± 1.4

98.3 ± 44/3.36 ± 1.4

117.2 ± 47/3.85 ± 1.3

< 0.001/< 0.001

Antibiotic treatment

 Beta-lactam

93.0%

93.0%

93.0%

1.0

 Macrolide

62.4%

61.5%

67.1%

0.2

 Fluoroquinolone

23.4%

23.5%

22.8%

0.9

 Other

11.8%

11.7%

12.0%

0.9

Laboratory data

 Hypoalbuminemia on admission (< 34 g/l)

36.2%

34.8%

39.9%

0.2

 Hyponatremia on admission (< 135 mmol/l)

37.9%

39.1%

31.0%

0.06

 Hemoglobin on admission/discharge (normal 13.0–16.2 g/dl)

12.5 ± 2/12.0 ± 2

12.5 ± 2/12.0 ± 2

12.4 ± 2/11.7 ± 2

0.4/0.02

 Anemia on admission/discharge

45.4%/61.4%

44.6%/60.5%

49.4%/65.8%

0.3/0.2

 WBC count on admission/discharge (normal 4−11 × 109/l)

12.5 ± 6/9.1 ± 4

12.6 ± 7/8.9 ± 4

12.2 ± 6/10.4 ± 6

0.4/< 0.001

 Neutrophil count on admission/discharge (normal 2.0–7.7 × 109/l)

10.4 ± 6/6.6 ± 4

10.5 ± 6/6.3 ± 3

10.1 ± 6/8.0 ± 6

0.5/< 0.001

 Platelet count on admission/discharge (normal 140−450 × 109/l)

229 ± 93/287 ± 122

230 ± 93/300 ± 123

226 ± 93/221 ± 86

0.6/< 0.001

 MPV on admission/discharge (normal 7.3–11.5 fL)

8.64 ± 1.2/8.48 ± 1.2

8.67 ± 1.3/8.29 ± 1.1

8.44 ± 0.9/9.46 ± 1.1

0.03/< 0.001

 MPV on admission ≤ 8.5/> 8.5 fL

51.7%/48.3%

50.7%/49.3%

57%/43%

0.1

 MPV on discharge ≤ 8.5/> 8.5 fL

57%/43%

64.3%/35.7%

19%/81%

< 0.001

 Duration between MPV measurements (days)

7.4 ± 9

7.2 ± 8

8.3 ± 10

0.2

In-hospital outcomes

 Transfer to intensive care unit

3.8%

3.7%

4.4%

0.6

 Mechanical ventilation

9.2%

6.8%

21.5%

< 0.001

 Duration of hospital stay (days)

8.1 ± 9

7.9 ± 8

9.0 ± 10

0.1

 Death

6.3%

3.3%

21.5%

< 0.001

  1. Data are presented as means ± SD or percentages of presented cases. MPV mean platelet volume; ΔMPV: MPV on discharge minus MPV on admission; CURB-65: assigning 1 point each for confusion, blood urea nitrogen > 19 g/dl, respiratory rate ≥ 30 breaths/min, low blood pressure and age ≥ 65 years; WBC white blood cell. Bold entries in the table indicate a p-value of ≤ 0.05