Characteristics | Entire sample (n = 976) | Group A No rising MPV ΔMPV < 0.6 fL (n = 818) | Group B Rising MPV ΔMPV ≥ 0.6 fL (n = 158) | Difference between groups A and B p-value |
---|---|---|---|---|
Age (years) | 64.6 ± 21 | 63.4 ± 20 | 70.7 ± 21 | < 0.001 |
Male sex | 52.3% | 51.2% | 57.6% | 0.1 |
Comorbid conditions | ||||
Renal dysfunction | 33.6% | 31.3% | 45.6% | < 0.001 |
Diabetes mellitus | 30.9% | 31.4% | 28.5% | 0.5 |
Coronary artery disease | 24.2% | 23.5% | 27.8% | 0.2 |
Chronic lung disease | 28.1% | 27.0% | 33.5% | 0.1 |
Heart failure | 16.8% | 15.8% | 22.2% | 0.06 |
Cerebrovascular disease | 16.9% | 15.2% | 25.9% | 0.001 |
History of malignancy | 8.4% | 8.2% | 9.5% | 0.6 |
Acute bleeding during hospitalization/blood transfusion | 3.3%/6.0% | 2.9%/5.7% | 5.1%/7.6% | 0.5/0.4 |
Pleural effusion/bilateral lung involvement | 25.8%/16.0% | 25.8%/15.5% | 25.9%/18.4% | 1.0/0.4 |
CURB-65 class | 1.78 ± 1.0 | 1.71 ± 1.0 | 2.15 ± 1.1 | < 0.001 |
Pneumonia Severity Index score/risk class | 100.1 ± 45/3.44 ± 1.4 | 98.3 ± 44/3.36 ± 1.4 | 117.2 ± 47/3.85 ± 1.3 | < 0.001/< 0.001 |
Antibiotic treatment | ||||
Beta-lactam | 93.0% | 93.0% | 93.0% | 1.0 |
Macrolide | 62.4% | 61.5% | 67.1% | 0.2 |
Fluoroquinolone | 23.4% | 23.5% | 22.8% | 0.9 |
Other | 11.8% | 11.7% | 12.0% | 0.9 |
Laboratory data | ||||
Hypoalbuminemia on admission (< 34 g/l) | 36.2% | 34.8% | 39.9% | 0.2 |
Hyponatremia on admission (< 135 mmol/l) | 37.9% | 39.1% | 31.0% | 0.06 |
Hemoglobin on admission/discharge (normal 13.0–16.2 g/dl) | 12.5 ± 2/12.0 ± 2 | 12.5 ± 2/12.0 ± 2 | 12.4 ± 2/11.7 ± 2 | 0.4/0.02 |
Anemia on admission/discharge | 45.4%/61.4% | 44.6%/60.5% | 49.4%/65.8% | 0.3/0.2 |
WBC count on admission/discharge (normal 4−11 × 109/l) | 12.5 ± 6/9.1 ± 4 | 12.6 ± 7/8.9 ± 4 | 12.2 ± 6/10.4 ± 6 | 0.4/< 0.001 |
Neutrophil count on admission/discharge (normal 2.0–7.7 × 109/l) | 10.4 ± 6/6.6 ± 4 | 10.5 ± 6/6.3 ± 3 | 10.1 ± 6/8.0 ± 6 | 0.5/< 0.001 |
Platelet count on admission/discharge (normal 140−450 × 109/l) | 229 ± 93/287 ± 122 | 230 ± 93/300 ± 123 | 226 ± 93/221 ± 86 | 0.6/< 0.001 |
MPV on admission/discharge (normal 7.3–11.5 fL) | 8.64 ± 1.2/8.48 ± 1.2 | 8.67 ± 1.3/8.29 ± 1.1 | 8.44 ± 0.9/9.46 ± 1.1 | 0.03/< 0.001 |
MPV on admission ≤ 8.5/> 8.5 fL | 51.7%/48.3% | 50.7%/49.3% | 57%/43% | 0.1 |
MPV on discharge ≤ 8.5/> 8.5 fL | 57%/43% | 64.3%/35.7% | 19%/81% | < 0.001 |
Duration between MPV measurements (days) | 7.4 ± 9 | 7.2 ± 8 | 8.3 ± 10 | 0.2 |
In-hospital outcomes | ||||
Transfer to intensive care unit | 3.8% | 3.7% | 4.4% | 0.6 |
Mechanical ventilation | 9.2% | 6.8% | 21.5% | < 0.001 |
Duration of hospital stay (days) | 8.1 ± 9 | 7.9 ± 8 | 9.0 ± 10 | 0.1 |
Death | 6.3% | 3.3% | 21.5% | < 0.001 |