A rise in mean platelet volume during hospitalization for community-acquired pneumonia predicts poor prognosis: a retrospective observational cohort study

Table 2 Variables that were most significantly associated with in-hospital outcomes in the entire study population (stepwise logistic regression analysis)

In-hospital outcomes	p-value	Relative risk	95% confidence interval
Transfer to intensive care unit (AUC = 0.73)
Age^a	0.011	0.587	0.46–0.75
Pneumonia Severity Index score^b	< 0.001	2.75	1.63–4.65
Coronary artery disease	0.027	3.00	1.32–6.82
Cerebrovascular disease	0.011	0.169	0.38–0.76
Hypoalbuminemia on admission	0.020	2.56	1.26–5.21
Mechanical ventilation (AUC = 0.86)
Pneumonia Severity Index score^b	< 0.001	4.27	2.98–6.11
ΔMPV ≥ 0.6 fL	< 0.001	2.62	1.54–4.45
Chronic lung disease	0.04	1.76	1.07–2.90
Cerebrovascular disease	0.037	1.70	1.00–2.56
Prolonged (> 7 days) hospital stay (AUC = 0.72)
Pneumonia Severity Index score^b	< 0.001	2.28	1.89–2.77
Chronic lung disease	0.004	1.61	1.18–2.21
Hypoalbuminemia on admission	0.01	1.44	1.06–1.95
Female sex	0.015	1.37	1.02–1.85
In-hospital death (AUC = 0.93)
ΔMPV ≥ 0.6 fL	< 0.001	6.79	3.48–13.20
Cerebrovascular disease	< 0.001	3.96	2.03–7.73
Pneumonia Severity Index score^b	< 0.001	3.90	2.29–6.64
Age^a	0.004	1.73	1.17–2.55

AUC: the area under the curve of the receiver operating characteristic plots; ΔMPV: MPV (mean platelet volume) on discharge minus MPV on admission. ^aFor each 10 year increment. ^bFor each 50 points increment

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