Fig. 3

Effect of Arg1 ablation in the lung on lung function as measured with the FlexiVent. PBS/OVA-treated Arg1-Con mice are represented by open diamonds connected by dashed lines and PBS/OVA-treated Arg1-KO^Tie2 mice by open squares connected by dotted lines. OVA/OVA-treated Arg1-Con mice are represented by filled diamonds and OVA/OVA treated Arg1-KO^Tie2 mice by filled squares both connected by continuous lines. Airway resistance R_N, tissue elastance H, and tissue resistance G are shown in panels A, B, and C, respectively. Values on the X-axis indicate the concentrations of aerosolized methacholine. Means ± SEM (n = 7-8 mice per group). Significance symbols: #: P < 0.01 (OVA/OVA vs. PBS/OVA Arg1-Con); *: P < 0.01 (OVA/OVA Arg1-KO^Tie2 vs. PBS/OVA Arg1-KO^Tie2); †: P < 0.01 (PBS/OVA Arg1-KO^Tie2 vs. PBS/OVA Arg1-Con). Arg1-KO^Tie2 and Arg1-Con mice did not differ in their response to OVA/OVA treatment