Fig. 4

Effect of Arg1 ablation in the lung on the expression of inflammatory genes. Black bars represent Arg1-Con mice and white bars Arg1-KO^Tie2 mice. mRNA abundance (AU = number of mRNA copies normalized to 18S rRNA expression and multiplied by 10⁴) of the T_H2-related inflammatory genes Il4, Il13, Il5 and Ccl11, the macrophage-chemotactic protein Ccl2, the anti-inflammatory gene Il10, the T_H1-related inflammatory genes Tnfa and Ifng, and the marker genes for the activation of bronchiolar epithelium Muc5ac and Clca3 are shown as means ± SEM (n = 7-8 mice per group). Significance symbols: *: P < 0.05 (OVA/OVA vs. PBS/OVA Arg1-Con); #: P < 0.05 (OVA/OVA vs. PBS/OVA Arg1-KO^Tie2); ‡: P < 0.05 (OVA/OVA Arg1-KO^Tie2 vs OVA/OVA Arg1-Con)